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Burn Degree Third clinical trials

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NCT ID: NCT05652816 Recruiting - Burn Degree Second Clinical Trials

Biological Skin Graft With Keratinocyte-stem Cell Co-cultre for Burn Patients

Start date: September 6, 2022
Phase: Early Phase 1
Study type: Interventional

The goal of this clinical trial is to test whether artificial skin graft can substitute autologous skin graft in current burn treatment. The main question it aims to answer is: • Can artificial skin graft result in better wound healing compared to the current burn treatment; autologous skin graft? You will: - Undergo debridement surgery - Receive artificial skin graft as an alternative to autologous skin graft - Undergo biopsy procedure of burn area If there is a comparison group: Researchers will compare autologous skin graft group to see the wound healing process

NCT ID: NCT05612867 Completed - Burns Clinical Trials

Low Dose Vitamin C in Burns >20% Compared to Previous Studies With High Dose Vitamin C

Start date: December 12, 2020
Phase:
Study type: Observational

Burn injury is marked by a large release of inflammatory mediators which disrupt the normal capillary barrier and cause a rapid shift of intravascular fluid into interstitial spaces, ultimately leading to shock and death. As such, adequate fluid management and resuscitation is critical for burn patients to prevent further cellular injury. Technologies and medical options such as cardiac output monitoring along with early tube feeding and vitamin C administration have developed slowly over the years. Effective management of the Systemic Inflammatory Response Syndrome response and metabolic derangement is crucial for the survival of burn patients. In particular, vitamin C administration has shown to significantly decreases early post-burn lipid peroxidation, reduce microvascular leak of fluid by preventing endothelial dysfunction, and decreases edema formation in burned tissue. Vitamin C is a cheap and widely available antioxidant which has been shown to significantly effective in positively impacting clinical outcomes in burn resuscitation. We aim to evaluate the efficacy of vitamin C in burns greater than 20% total body surface area on clinical outcomes such as length of hospital stay, total fluid requirements, and mortality.

NCT ID: NCT04200053 Completed - Burn Degree Second Clinical Trials

The Effect of Reflexology Massage and Passive Music Therapy Intervention Before Burn Dressing

Start date: August 12, 2019
Phase: N/A
Study type: Interventional

Reflexology massage applied before burn dressing reduces pain, anxiety and sleep problems