Phase 3, Randomized, Double Blinded, Active Controlled, Multicenter Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of EXPAREL Admixed With Bupi vs. Bupi Only Administered as Combined Sciatic and Adductor Canal Nerve Block for Postsurgical Analgesia in Lower Extremity Surgeries

Bunion Clinical Trial

— STRIDE  

Official title:

A Phase 3, Randomized, Double Blinded, Active Controlled, Multicenter Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of EXPAREL Admixed With Bupivacaine vs. Bupivacaine Only Administered as Combined Sciatic (in Popliteal Fossa) and Adductor Canal Nerve Block for Postsurgical Analgesia in Subjects Undergoing Lower Extremity Surgeries

Clinical Trial Details — Status: Withdrawn

Administrative data

• NCT number: NCT03954639
• Other study ID #: 402-C-332
• Status: Withdrawn
• Phase: Phase 3
• Start date: June 15, 2020
• Est. completion date: September 2020

Study information

• Verified date: May 2020
• Source: Pacira Pharmaceuticals, Inc
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This is a Phase 3, multicenter, randomized, double blinded, active controlled study in approximately 81 subjects undergoing lower extremity surgeries with combined sciatic and adductor canal nerve block.

Recruitment information / eligibility

• Status: Withdrawn
• Enrollment: 0
• Est. completion date: September 2020
• Est. primary completion date: September 2020
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

1. Healthy adult male or female volunteers ages 18 or older

2. American Society of Anesthesiologists (ASA) physical status 1, 2 or 3.

3. Able to provide informed consent, adhere to the study schedule, and complete all study assessments.

4. Body Mass Index =18 and =40 kg/m2

Exclusion Criteria:

1. Allergy, hypersensitivity, intolerance, or contraindication to any of the study medications for which an alternative is not named in the protocol (eg, amide-type local anesthetics, opioids, bupivacaine, NSAIDs)

2. Documented history of long-term diabetes, renal (serum creatinine level >2mg/dL [176.8 µmol/L]) or hepatic dysfunction (serum alanine or aspartame transferase > 3 times the upper limit of normal), coagulation or bleeding disorder and severe peripheral vascular disease

3. Concurrent painful physical condition that may require analgesic treatment (such as long-term, consistent use of opioids) in the post dosing period for pain and which, in the investigator's opinion may confound the post dosing assessments

4. History of, suspected, or known addiction to or abuse of illicit drug(s), prescription medicine(s), or alcohol within the past 2 years

5. Administration of an investigational drug within 30 days or 5 elimination half-lives of such investigational drug, whichever is longer, prior to study drug administration, or planned administration of another investigational product or procedure during the subject's participation in this study

6. Previous participation in EXPAREL study

7. Uncontrolled anxiety, schizophrenia, or other psychiatric disorder that, in the opinion of the investigator, could interfere with study assessments or compliance

8. Currently pregnant, nursing, or planning to become pregnant during the study

9. Clinically significant medical disease that, in the opinion of the investigator, would make participation in a clinical study inappropriate. This includes any psychiatric or other conditions that would constitute a contraindication to participation in the study

10. Currently on neuroleptic agent [e.g., gabapentin, pregabalin (Lyrica), duloxetine (Cymbalta) etc.]

11. Inadequate sensory function on the foot (monofilament test)

12. Chronic opioid use in the last 30 days (=30 morphine equivalents/ day)

In addition, the subject may be withdrawn from the study if the subject meets the following criterion during or post-surgery:

13. Any clinically significant event or condition uncovered during the surgery (e.g., excessive bleeding, acute sepsis) that, in the opinion of the investigator, renders the subject medically unstable or complicates the subject's post-operative course

Related Conditions & MeSH terms

• Bunion
• Forefoot Surgery
• Hindfoot Fusion
• Metatarsophalangeal Fusion
• Midfoot Fusion
• Total Ankle Arthroplasty

Intervention

Drug:
• EXPAREL 13.3Mg/mL Suspension for Injection
Combined Sciatic and Adductor Canal Nerve Block with EXPAREL mixed with Bupivacaine (Single Dose)
• Bupivacaine Hydrochloride
Combined Sciatic and Adductor Canal Nerve Block with Bupivacaine HCL

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Pacira Pharmaceuticals, Inc

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Magnitude of analgesic effect	Area under the Curve of the NRS Pain intensity scores from 0 hours to 96 hours post-surgery.	0 hours to 96 hours
Secondary	Total Postsurgical Opioid Consumption	Total Postsurgical opioid consumption from 0 hours to 96 hours post-surgery	0 hours to 96 hours