Clinical Trials Logo

Clinical Trial Summary

Bruxism is defined as a parafunction that consists of a clenching of the jaw and/or grinding of the teeth. It can occur when an individual is sleeping or awake or it can be mixed. Most often, it is primary or idiopathic bruxism, however when it is related to a cause it is qualified as secondary. Primary bruxism is a condition that is not well known to the general public, but I is very widespread (12% of the adult population). In addition, it can alter quality of life, as a result of associated sleep disorders, concentration disorders, daytime fatigue, chronic pain, etc. The current treatment for this condition is only symptomatic. Currently, one of the most effective treatments is the intramuscular injection of botulinum toxin A in the muscles of mastication. The progressive anticholinergic action results in a reduction of functional signs (dental pain, periodontal pain, temporomandibular joint pain, tension headaches, neck pain) and physical signs (reduction of the mass of the injected muscles, alba linea, tongue scalloping, limitation or stability of dental damage). However, these clinical data are practically not objectified in daily practice. Objective criteria would make it possible to measure the effectiveness of the treatment, to follow the patient, and to identify the early symptoms in order to prevent a recurrence. The aim of the prospective study is to concretely measure the strength and electromyographic activity of the muscles of mastication before and after botulinum toxin injection.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT04722809
Study type Interventional
Source Centre Hospitalier Universitaire Dijon
Contact Narcisse ZWETYENGA
Phone 03 80 29 37 57
Email narcisse.zwetyenga@chu-dijon.fr
Status Recruiting
Phase Phase 3
Start date May 25, 2022
Completion date February 2024

See also
  Status Clinical Trial Phase
Completed NCT05760482 - Evaluation of the Relationship Between Bruxism and Tryptophan Metabolites N/A
Enrolling by invitation NCT02235220 - Reduction of Masticatory Muscle Activity by Restoring Canine Guidance N/A
Recruiting NCT05604729 - The Effect on Envelope of Motion in Asymptomatic Bruxers N/A
Recruiting NCT05995431 - Impact of Bruxism in the Outcome of Subgingival Instrumentation for the Management of Stage 2 and Stage 3 Periodontitis. N/A
Not yet recruiting NCT05764694 - Correlation Between the Occurrence of School Bullying, Victimization, and the Occurrence of Deleterious Oral Habits.
Completed NCT06258070 - Clinical Performance of Therapeutic Use of BTX for Bruxism N/A
Completed NCT04363931 - Investigation of the Effects of Kinesio Taping and Manual Therapy in Patients With Bruxism N/A
Terminated NCT01005511 - Treatment Period and Long-term Efficacy of Functional Electrical Stimulation (FES) on Sleep Bruxism N/A
Not yet recruiting NCT06052709 - Investigation of Occupational Balance in Individuals With and Without Bruxism N/A
Recruiting NCT06037798 - The Cranio-cervical Flexion Test Using the NOD Device
Recruiting NCT03006133 - Prevalence of Bruxism in a Group of Preschool Egyptian Children N/A
Completed NCT02257320 - TMJ NextGeneration(TM) Feasibility Study N/A
Completed NCT04884152 - Telerehabilitation in Individuals Temporomandibular Dysfunction With Bruxism N/A
Completed NCT01463826 - Respiratory Problems and Caries in Children With Bruxism N/A
Completed NCT05416788 - Effect of Cervical Manipulation on Mouth Opening N/A
Not yet recruiting NCT06386809 - Effectiveness of Transcutaneous Auricular Vagus Nerve Stimulation in Bruxism N/A
Recruiting NCT05562531 - Botulinum Toxin Administration on Masticatory Performance
Enrolling by invitation NCT06377475 - Fabrication and Insertion of Michigan Splints by Dental Students
Completed NCT04790110 - 7 Year Follow up Analysis on the Speed of Progression of Tooth Wear Using 3D Subtraction
Active, not recruiting NCT03713827 - Clinical Performance of a Glass Hybrid Restorative in NCCL's of Patients With Bruxism N/A