Clinical Trial Details
— Status: Recruiting
Administrative data
| NCT number |
NCT02809625 |
| Other study ID # |
AHInnerMongolia |
| Secondary ID |
|
| Status |
Recruiting |
| Phase |
|
| First received |
|
| Last updated |
|
| Start date |
March 2016 |
| Est. completion date |
December 2024 |
Study information
| Verified date |
July 2023 |
| Source |
The Affiliated Hospital of Inner Mongolia Medical University |
| Contact |
Peng fei Qiao, MD |
| Phone |
+86-15904718239 |
| Email |
qpfff[@]126.com |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Observational
|
Clinical Trial Summary
Brucellosis, also known as Mediterranean fever, undulant fever, or Malta fever is a zoonotic
disease caused by Brucella infection.With the rapid development of animal husbandry and
aquaculture and increasing consumption of dairy products in urban residents, the incidence of
this disease in Inner Mongolia and even in the mainland area of China is significantly
increased.
The disease can damage multiple systems including nervous system, circulatory system,
reproductive system and bone joints, etc. The sooner the diagnosis of brucellar spondylitis
is diagnosed and treated, the better will be the prognosis of the patients which can prevent
the development of severe complications and diminish the need for surgical therapy. Thus the
early diagnosis of brucellar spondylitis was of great significance.We quantitatively analyzed
the brucellar spondylitis with DCE-MRI to explore the application of DCE-MRI in the early
diagnosis of brucellar spondylitis.
Description:
About 100 patients with Brucellosis were conducted with conventional MRI and dynamic
contrast-enhanced MRI(DCE-MRI) scan. The variations of the value of ktrans（endothelial
transfer constant），kep（reflux rate）,Ve(fractional extracellular fluid space volume) and
Vp(fractional plasma volume) between the vertebral lesions,Early lesions of vertebral body
and normal tissues were measured and compared. And under the receiver operating
characteristic（ROC） curve analysis,we will calculate the sensitivity and specificity of
Ktrans,Kep,Ve and Vp in the diagnosis and early diagnosis of brucella spondylitis .The values
of Ktrans,Kep,Ve and Vp will be studied between the vertebral lesions and normal tissues, the
early lesions of vertebral body and normal tissues.The sensitivity and specificity of both
parameters (Ktrans、Kep、Ve、Vp)will be done.The valve of DCE-MRI in the diagnosis and early
diagnosis of the brucella spondylitis will be analysed.
