Clinical Trials Logo
  1. Home
  2. Brown Adipose Tissue
  3. NCT03269747

Short Term Effect of Glucocorticoids on Brown Adipose Tissue Thermogenesis in Humans — GlucoBAT  

Brown Adipose Tissue Clinical Trial

Official title:
Short Term Effect of Glucocorticoids on Brown Adipose Tissue Thermogenesis in Humans

Clinical Trial Summary

Interventional, Placebo controlled cross-over study to investigate the short-term effects of glucocorticoids (prednisone) on human brown adipose tissue.

Clinical Trial Description

Active brown adipose tissue (BAT) has recently been unambiguously discovered in human adults. Active BAT increases energy expenditure and improves glucose tolerance. Pharmacological use of glucocorticoids (GCs) is widespread in clinical practice due to their high anti-inflammatory efficacy. While short-term administration even of high doses usually is well tolerated, long-term use of medium to high amounts of GCs leads to unfavorable metabolic changes, characterized by an increase in intra-abdominal fat mass, a decrease in muscle mass and insulin resistance.

In line with these well-known side-effects of GCs, several in vitro studies and animal models demonstrate an inhibiting effect of GCs on BAT thermogenesis. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03269747
Study type Interventional
Source University Hospital, Basel, Switzerland
Contact
Status Completed
Phase Phase 4
Start date December 6, 2017
Completion date April 16, 2019
View Details
See also
  Status Clinical Trial Phase
Completed NCT02038595 - The Norepinephrine Transporter: A Novel Target for Imaging Brown Adipose Tissue Early Phase 1
Completed NCT02964442 - Brown Adipose Tissue Activation and Energy Expenditure by Capsinoids Stimulation With Trimodality Imaging Using 18-FDG-PET, Fat Fraction MRI and Infrared Thermography N/A
Recruiting NCT06078345 - Brown Adipose Tissue as Nutrient Buffer Through Diet Induced Thermogenesis N/A
Active, not recruiting NCT03541096 - Winter-Swimming and Brown Adipose Tissue Activity in Middel-aged Obese Subjects (WinterBAT). N/A
Completed NCT04766021 - Mirabegron and Physiological Function in Cold Environments Phase 1/Phase 2
Completed NCT01898949 - Stimulation of Diet-Induced Thermogenesis by Cold-Exposure N/A
Recruiting NCT05711199 - Effect of Glyceroltrinitrate on Human Energy Expenditure and Brown Adipose Tissue Thermogenesis Early Phase 1
Completed NCT05990387 - MIrabegron and Physiological Function in Cold Environments Phase 1/Phase 2
Recruiting NCT04595006 - Brown Fat Activation and Browning Efficiency Augmented by Chronic Cold and Nutraceuticals for Brown Adipose Tissue-mediated Effect Against Metabolic Syndrome (BEACON BEAMS Study) N/A
Completed NCT02381483 - Vitamin A in Brown Fat Activity N/A
Recruiting NCT05517967 - An Examination of Brown Adipose Tissue and Energy Expenditure in Infants
Completed NCT03490227 - Measurement of Body Fat in Infants
Completed NCT03096535 - Cold Induced Activation of Brown Adipose Tissue in Humans N/A
Completed NCT03095846 - Cold Induced Activation of Brown Adipose Tissue in Winter Swimmers N/A