Bronchoscopy Clinical Trial
Official title:
Safety and Efficacy of Remimazolam Compared With Midazolam During Bronchoscopy: A Single Center, Randomized Controlled Study
Objectives: Although remimazolam is an ultra-short-acting benzodiazepine with a shorter elimination half-life and faster recovery time than midazolam, studies evaluating its safety and efficacy during bronchoscopy are limited. This study compared the safety and efficacy of remimazolam with that of midazolam for bronchoscopy. Design: A single-center, prospective randomized parallel-group study Setting: Chungbuk National University Hospital, April 2022-June 2023. Participants: One hundred patients were enrolled; 51 were randomly assigned to the midazolam group and 49 to the remimazolam group. Respiratory nurse specialists performed the randomization. Interventions: Oral and laryngeal anesthesia was induced using a 4% lidocaine nebulizer prior to sedation. The vocal cords and lower airway tract were anesthetized. Patients aged <60 years or weighing >50 kg received 3 mg intravenous midazolam or 5 mg remimazolam. Patients aged ≥60 years or weighing <50 kg received 2 mg intravenous midazolam or 3 mg remimazolam. Bronchoscopy was performed under adequate sedation (MOAA/S≤3) Main outcome measures: The primary outcome was the time from the end of the procedure to full alertness. Secondary outcomes were procedural time parameters, satisfaction profiles, and adverse effects.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Terminated |
NCT03581474 -
Evaluation of BAL Procedure With Ambu aScope 3 Large in Patients in an ICU Setting
|
N/A | |
| Completed |
NCT03294213 -
Prospective Non-interventional Evaluation of Intubation and Intensive Care Use of the New aScope™ 4 Broncho and aView
|
||
| Completed |
NCT06116955 -
The Application of Balanced Propofol Sedation in Fiberoptic Bronchoscopy
|
||
| Withdrawn |
NCT03613792 -
Remifentanil Plus Ketamine for Dynamic Flexible Bronchoscopy
|
Phase 4 | |
| Completed |
NCT04016480 -
HFNC During Bronchoscopy for Bronchoalveolar Lavage
|
N/A | |
| Recruiting |
NCT01100554 -
Upper Airway Collapsibility Evaluation in Different Sedative Levels by Sleep Endoscopy
|
N/A | |
| Completed |
NCT00861835 -
Trial of Rapid On-Site Evaluation of Transbronchial Needle Aspirate (TBNA)
|
N/A | |
| Completed |
NCT05154916 -
The Effect of Virtual Reality Based Relaxation Program on Patients to be Performed Bronchoscopy
|
N/A | |
| Completed |
NCT03086408 -
Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) and Diagnostic Bronchoscopy
|
N/A | |
| Active, not recruiting |
NCT04884061 -
Narrow Band Imaging Bronchoscopy During SARS-CoV2 Infection
|
||
| Completed |
NCT05875662 -
Pulmonary Ventilation After Fiberoptic Bronchoscopy Using EIT
|
||
| Completed |
NCT00684684 -
Safety and Feasibility Study of the Chartis System
|
Phase 1 | |
| Completed |
NCT03521505 -
Dexmedetomidine for Sedation of Endobronchial Ultrasound-guided Transbronchial Needle Aspiration
|
Phase 4 | |
| Not yet recruiting |
NCT03856073 -
The Training and Evaluate Effect on Clinical Airway Management for Novices.
|
N/A | |
| Not yet recruiting |
NCT03854760 -
The Training and Evaluate Effect on Clinical Airway Management
|
N/A | |
| Recruiting |
NCT05912985 -
Three Different Oxygenation Strategies in Bronchoscopy Procedures Under Sedation
|
||
| Enrolling by invitation |
NCT05692362 -
Measure Airway Compliance by Endobronchial Optical Coherence Tomography
|
||
| Completed |
NCT03419546 -
Clinical Validation Trial of a Single-use Bronchoscope (Ambu® aScope ™ 4)
|
||
| Completed |
NCT03886454 -
Incidence and Nature of Respiratory Impairment in Consecutive Patients Undergoing Bronchoscopy Under Conscious Sedation: A Pilot Study
|
||
| Not yet recruiting |
NCT03983915 -
Sedation Strategies for Therapeutic Bronchoscopy 2
|
N/A |