Body Weight Growth After Birth and Bronchopulmonary Dysplasia

Bronchopulmonary Dysplasia Clinical Trial

Official title:

Association of Body Weight Growth After Birth and Bronchopulmonary Dysplasia(BPD)

Clinical Trial Details — Status: Withdrawn

Administrative data

• NCT number: NCT05053269
• Other study ID #: 2020228
• Status: Withdrawn
• Start date: October 1, 2021
• Est. completion date: December 31, 2024

Study information

• Verified date: October 2022
• Source: Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Bronchopulmonary dysplasia (BPD) is one of the most common, complex, and severe diseases in preterm infants. BPD was first described as chronic pulmonary disease in survivors of severe respiratory distress syndrome (RDS) in 1967, which was also called as the "old" BPD. In recent years, the definition for BPD has developed a lot. The National Institute of Child Health and Human Development (NICHD) workshop in 2018 assessed BPD at 36 post-menstrual age (PMA) along with radiographic confirmation and used a severity grading of I-III. Although with effective surfactant supplement and oxygen support, BPD brings a great challenge to neonatologists.

Description:

Besides persistent inflammation, prolonged invasive ventilation and oxidative damage. body weight is the one of the most important factors to induce BPD. Poor extrauterine growth is commonly described in extremely preterm infants. But, the relationship of postnatal growth with BPD and respiratory morbidity is not entirely understood.

The aim of the present study is to assess whether body weight growth after birth is the risk factor for BPD.

Recruitment information / eligibility

• Status: Withdrawn
• Enrollment: 0
• Est. completion date: December 31, 2024
• Est. primary completion date: December 31, 2024
• Gender: All
• Age group: 1 Minute to 1 Day

Eligibility

Inclusion Criteria:

• equal to or less than 32 weeks' gestational age

Exclusion Criteria:

• main congenital malformation

• parents' refusal

Related Conditions & MeSH terms

• Body Weight
• Bronchopulmonary Dysplasia
• Preterm

Intervention

Other:
• good body weight growth
body weight growth after birth is consistent with the growth curve
• poor body weight growth
body weight growth after birth is inconsistent with the growth curve

Locations

Country	Name	City	State
China	Children's Hospital of Chongqing Medical University	Chongqing	Chongqing

Sponsors (2)

Lead Sponsor	Collaborator
Daping Hospital and the Research Institute of Surgery of the Third Military Medical University	Children's Hospital of Chongqing Medical University

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	the incidence of BPD	the infant was diagnosed with BPD	up to 36 weeks' gestational age
Secondary	body weight growth after birth	to assess whether body weight growth after birth is consistent with the growth curve	up to 36 weeks' gestational age