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NCT04936477 Clinical Trial

Ventilation-perfusion (V/Q) Ratio and Alveolar Surface Area in Preterm Infants

Bronchopulmonary Dysplasia Clinical Trial

Official title:
Functional Morphometry and Ventilation Perfusion Ratio to Estimate the Alveolar Surface Area in Prematurely Born Infants

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT04936477
Other study ID # KCH20-138
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date September 29, 2020
Est. completion date January 30, 2023

Study information
Verified date August 2022
Source King's College London
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

To non-invasively estimate the alveolar surface area of the lungs of prematurely born infants by taking measurements of oxygen and carbon dioxide and utilizing functional morphometry.

Recruitment information / eligibility
Status Completed
Enrollment 30
Est. completion date January 30, 2023
Est. primary completion date June 30, 2022
Accepts healthy volunteers No
Gender All
Age group 22 Weeks to 28 Weeks
Eligibility Inclusion Criteria: - Exclusion Criteria: - Congenital or chromosomal anomalies

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• Calculation of ventilation-perfusion ratio
Three to five paired measurements of fraction of inspired oxygen and peripheral oxygen saturations. Insertion of mainstream capnograph with combined pressure and flow sensor to perform end-tidal capnography measurement. Echocardiogram to assess intra-cardiac shunting.

Locations
Country Name City State
United Kingdom King's College Hospital NHS Foundation Trust London

Sponsors (2)
Lead Sponsor Collaborator
King's College London King's College Hospital NHS Trust

Country where clinical trial is conducted

United Kingdom, 

Outcome
Type Measure Description Time frame Safety issue
Primary Calculation of the alveolar surface area in prematurely born infants using validated functional morphometry One year
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