Clinical Trials Logo
  1. Home
  2. Bronchopulmonary Dysplasia
  3. NCT04936477
  4. Details
NCT04936477 Clinical Trial

Ventilation-perfusion (V/Q) Ratio and Alveolar Surface Area in Preterm Infants

Bronchopulmonary Dysplasia Clinical Trial

Official title:
Functional Morphometry and Ventilation Perfusion Ratio to Estimate the Alveolar Surface Area in Prematurely Born Infants

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT04936477
Other study ID # KCH20-138
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date September 29, 2020
Est. completion date January 30, 2023

Study information
Verified date August 2022
Source King's College London
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

To non-invasively estimate the alveolar surface area of the lungs of prematurely born infants by taking measurements of oxygen and carbon dioxide and utilizing functional morphometry.

Recruitment information / eligibility
Status Completed
Enrollment 30
Est. completion date January 30, 2023
Est. primary completion date June 30, 2022
Accepts healthy volunteers No
Gender All
Age group 22 Weeks to 28 Weeks
Eligibility Inclusion Criteria: - Exclusion Criteria: - Congenital or chromosomal anomalies

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• Calculation of ventilation-perfusion ratio
Three to five paired measurements of fraction of inspired oxygen and peripheral oxygen saturations. Insertion of mainstream capnograph with combined pressure and flow sensor to perform end-tidal capnography measurement. Echocardiogram to assess intra-cardiac shunting.

Locations
Country Name City State
United Kingdom King's College Hospital NHS Foundation Trust London

Sponsors (2)
Lead Sponsor Collaborator
King's College London King's College Hospital NHS Trust

Country where clinical trial is conducted

United Kingdom, 

Outcome
Type Measure Description Time frame Safety issue
Primary Calculation of the alveolar surface area in prematurely born infants using validated functional morphometry One year
See also
  Status Clinical Trial Phase
Terminated NCT04506619 - Safety and Efficacy Outcomes Following Previously Administered Short-Term Treatment With SHP607 in Extremely Premature Infants
Recruiting NCT05285345 - Implementation of a Consensus-Based Discharge Protocol for Preterm Infants With Lung Disease
Completed NCT03649932 - Enteral L Citrulline Supplementation in Preterm Infants - Safety, Efficacy and Dosing Phase 1
Terminated NCT02524249 - Early Versus Late Caffeine for ELBW Newborns N/A
Completed NCT02249143 - Duration of Continuous Positive Airway Pressure and Pulmonary Function Testing in Preterm Infants N/A
Active, not recruiting NCT01632475 - Follow-Up Study of Safety and Efficacy of Pneumostem® in Premature Infants With Bronchopulmonary Dysplasia
Completed NCT01460576 - Improving Prematurity-Related Respiratory Outcomes at Vanderbilt N/A
Completed NCT00419588 - Growth of Airways and Lung Tissues in Premature and Healthy Infants
Unknown status NCT00254176 - Cysteine Supplementation in Critically Ill Neonates Phase 2/Phase 3
Completed NCT00319956 - Trial II of Lung Protection With Azithromycin in the Preterm Infant Phase 2
Completed NCT00208039 - Pilot Trial of Surfactant Booster Prophylaxis For Ventilated Preterm Neonates N/A
Completed NCT00006401 - Inhaled Nitric Oxide for Preventing Chronic Lung Disease in Premature Infants Phase 3
Terminated NCT05030012 - Maintaining Optimal HVNI Delivery Using Automatic Titration of Oxygen in Preterm Infants N/A
Completed NCT00006058 - Study of the Pathobiology of Bronchopulmonary Dysplasia in Newborns N/A
Completed NCT00005376 - Premature Birth and Its Sequelae in Women N/A
Completed NCT00011362 - Dexamethasone Therapy in VLBW Infants at Risk of CLD Phase 3
Completed NCT00004805 - Study of the Effect of Four Methods of Cardiopulmonary Resuscitation Instruction on Psychosocial Response of Parents With Infants at Risk of Sudden Death N/A
Completed NCT05152316 - The Baby Lung Study
Recruiting NCT04821453 - NAVA vs. CMV Crossover in Severe BPD N/A
Active, not recruiting NCT04662151 - A Clinical Safety Study of AT-100 (rhSP-D) in Preterm Neonates at High Risk for Bronchopulmonary Dysplasia (BPD) Phase 1