Bronchopulmonary Dysplasia Clinical Trial
Official title:
Infant Flow Biphasic NCPAP Versus Infant Flow NCPAP for the Facilitation of Successful Extubation in Infants </= 1250 Grams: A Randomized Controlled Trial
The purpose of this study is to compare two methods of delivering Nasal Continuous Airway Pressure (NCPAP): Biphasic Mode and a continuous mode, to see which is better in getting babies off the ventilator and decreasing lung damage.
Chronic lung disease (CLD) remains a significant problem among low birth weight infants with
a reported incidence of up to 26% in infants < 1500 grams. Nasal continuous positive airway
pressure (NCPAP) has been demonstrated to provide effective non-invasive respiratory support
for preterm infants. The use of NCPAP is associated with a decreased need for mechanical
ventilation and may impact on the incidence of CLD. There are two types of NCPAP now
available, a Biphasic mode which allows for cycling at two different levels of positive
pressure and a continuous mode which allows only for one level of positive pressure.
Comparisons: Biphasic NCPAP will be compared with continuous CPAP to see which better
facilitates the extubation of preterm infants who weigh </= 1250 grams at birth. The
incidence of CLD, retinopathy of prematurity, sepsis, intraventricular haemorrhage,
periventricular leucomalacia and necrotizing entercolitis will also be compared between the
two groups.
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Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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