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Bronchopulmonary Dysplasia clinical trials

View clinical trials related to Bronchopulmonary Dysplasia.

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NCT ID: NCT01607216 Completed - Clinical trials for Bronchopulmonary Dysplasia

Functional and Lymphocytic Markers of Respiratory Morbidity in Hyperoxic Preemies

Start date: August 2011
Phase:
Study type: Observational

This is an observational study that proposes to collect clinical, physiological, cellular and molecular information in an attempt to identify a set of factors that may predict the risk for persistent lung disease in babies born prematurely.

NCT ID: NCT01600430 Completed - Clinical trials for Vitamin D Deficiency

Vitamin D Supplementation for Extremely Preterm Infants

Start date: June 2012
Phase: Phase 2/Phase 3
Study type: Interventional

The study hypothesis states that giving early enteral Vitamin D supplementation to preterm infants will decrease respiratory morbidity in extremely preterm infants.

NCT ID: NCT01516398 Completed - Clinical trials for Hypertension, Pulmonary

Predictors of Pulmonary Hypertension Risk in Premature Infants With Bronchopulmonary Dysplasia

Start date: July 2011
Phase:
Study type: Observational

A lung condition called bronchopulmonary dysplasia (BPD) is a major cause of poor outcomes and death for premature infants. Infants with BPD are also at high risk for pulmonary hypertension (PH)-an important contributor to their condition. Previous research has suggested that a protein in the blood, endothelin-1 (ET-1), is associated with pulmonary disease. This study aims to investigate the incidence of PH and levels of ET-1 among premature babies with BPD. It will also potentially allow us to focus further research efforts and treatment towards these infants, some of our sickest patients at LPCH.

NCT ID: NCT01503801 Completed - Pulmonary Disease Clinical Trials

Inhaled Nitric Oxide to Prevent and Treat Bronchopulmonary Dysplasia

NO-BPD
Start date: May 2011
Phase: Phase 2/Phase 3
Study type: Interventional

Inhaled nitric oxide in preterm babies with respiratory failure or ventilator dependence will: 1. decrease the incidence of Bronchopulmonary Dysplasia (BPD) or death 2. shorten the length of oxygen therapy and hospital stay ,reduce the cost of hospital stay without increasing adverse effect

NCT ID: NCT01473264 Completed - Clinical trials for Bronchopulmonary Dysplasia

Safety, Pk and Anti-inflammatory Effects of CC10 Protein in Premature Infants With Respiratory Distress Syndrome (RDS)

Start date: January 2000
Phase: Phase 1/Phase 2
Study type: Interventional

Bronchopulmonary Dysplasia (BPD) is a multi-factorial disease process that is the end result of an immature, surfactant deficient lung that has been exposed to hyperoxia, mechanical ventilation and infection. These conditions initiate an inflammatory response characterized by elevated inflammatory cell infiltrates and proinflammatory cytokines that lead to the development of significant acute and chronic lung injury. The study drug, rhCC10, is a recombinant version of natural human CC10 protein. Native CC10 is produced primarily by non-ciliated respiratory epithelial cells, called Clara cells and is the most abundant protein in the mucosal fluids in normal healthy lungs. The purpose of this study was to evaluate the pharmacokinetics, safety, tolerability and anti-inflammatory effects of a single intratracheal (IT) dose of rhCC10 to intubated premature infants receiving positive pressure ventilation for treatment of respiratory distress syndrome (RDS) to prevent long term respiratory complications referred to as bronchopulmonary dysplasia, and, more recently, as chronic respiratory morbidity (CRM; asthma, cough, wheezing, multiple respiratory infections). CC10 regulates inflammatory responses and protects the structural integrity of pulmonary tissue while preserving pulmonary mechanical function during various insults (eg. viral infection, bacterial endotoxin, ozone, allergens, hyperoxia). Together these properties suggest that administration of rhCC10 may help to facilitate development of normal airway epithelia and prevent the inflammation that leads to CRM in these infants.

NCT ID: NCT01460576 Completed - Preterm Birth Clinical Trials

Improving Prematurity-Related Respiratory Outcomes at Vanderbilt

IMPROV
Start date: September 2011
Phase: N/A
Study type: Observational

The goal of IMPROV is to identify molecular mechanisms that contribute to lung injury and long-term breathing problems in preterm infants by investigating two interrelated biochemical pathways: the urea cycle-nitric oxide pathway and the glutathione pathway. The investigators hypothesize that prematurity-related limitations in the function of these important biochemical pathways contribute to respiratory disease risk over the first year of life.

NCT ID: NCT01440647 Completed - Clinical trials for Bronchopulmonary Dysplasia

Study of Nasal Ventilation In Preterm Infants To Decrease Time on The Respirator

Start date: November 2007
Phase: N/A
Study type: Interventional

Very premature infants often cannot breathe on their own and require assistance with a respirator. Conventional respirators deliver air or oxygen via a breathing tube placed through the mouth to the airway (endotracheal tube). A prolonged use of an endotracheal tube is associated with injury to the lungs. Currently, a premature baby has to be ventilated through an endotracheal tube until he/she can fully breathe independently. In the current study, in order to shorten the time with an endotracheal tube, we utilized an alternative, less invasive ventilation procedure, nasal intermittent positive pressure ventilation (NIPPV). This procedure provides help with breathing, but requires only nasal, not endotracheal tubes. We hypothesized that NIPPV might help babies breathe, at an early stage in their recovery, when they could not breathe independently yet. Thus, by switching babies at this early stage from a regular respirator to NIPPV, we should be able to shorten the use of an injurious endotracheal tube.

NCT ID: NCT01439295 Completed - Clinical trials for Bronchopulmonary Dysplasia

Ascorbyl Peroxide Association With Bronchopulmonary Dysplasia

Start date: August 2010
Phase: N/A
Study type: Observational

Urinary ascorbyl peroxide level in the first week of life will be a good predictor of Bronchopulmonary dysplasia (BPD) in preterm infants less than 33 weeks of gestation.

NCT ID: NCT01424553 Completed - Clinical trials for Bronchopulmonary Dysplasia

Respiratory Outcome at Adolescence of Very Low Birthweight Infants

EPIPAGEADO
Start date: October 2011
Phase: N/A
Study type: Interventional

EPIPAGEADO is an observational study. Respiratory symptoms and lung function will be evaluated in very low birth weight and term infants, born in 1997 and included in the French EPIPAGE cohort.

NCT ID: NCT01383850 Completed - Clinical trials for Bronchopulmonary Dysplasia

NCPAP + Heliox as a Treatment for Infant Respiratory Distress Syndrome (RDS)

Start date: February 2008
Phase: Phase 2
Study type: Interventional

Infants born between 28 and 32 weeks' gestation with radiological findings and clinical symptoms of moderate RDS, requiring respiratory support with Nasal Continuous Positive Airway Pressure (NCPAP) within the first hour of life, were randomized to receive either standard medical air or a Heliox/Oxygen mixture 80/20 (Heliox) during the first 12 hours of life, followed by medical air until NCPAP was needed. The aim of the study was to assess the therapeutic effects of breathing a low-density gas mixture (heliox: 80% helium and 20% oxygen) in premature babies with Respiratory Distress Syndrome (RDS), undergoing NCPAP in terms of reducing the rate of mechanical ventilation (MV).