Infant, Premature Clinical Trial
Official title:
Physiologic Definition of Bronchopulmonary Dysplasia
This observational study was conducted to design and test a physiologic definition for bronchopulmonary dysplasia at 36 weeks of life. Infants were studied in a supine position with the pulse oximeter in position with good signal prior to collecting baseline data. Feedings and medications were given 30 minutes before the evaluation. Baseline data was collected on infant's current oxygen. Then, the infants were weaned to room air for 30 minutes. If saturations remain ≥90%, the infant was considered to have passed the oxygen reduction challenge (to NOT have BPD). The infant should then be placed back in his/her baseline oxygen. If the infant has saturations <90% for 5 continuous minutes or <80% for 15 seconds, the infant should be immediately placed back in his/her baseline oxygen, and the infant was considered to have NOT passed the challenge (to have BPD).
One of the confounders to any study that looks at bronchopulmonary dysplasia (BPD) is the
lack of a precise definition. Most neonates with BPD do not undergo lung biopsy or any
physiologic test; thus, their pulmonary disease is defined clinically, on the basis of the
sustained need for supplemental oxygen at 36 weeks postmenstrual age. The validity of this
definition is supported by evidence that oxygen dependence at 36 weeks is predictive of
long-term impairment in pulmonary function. An inherent limitation of defining BPD by the
need for supplemental oxygen is that the need for oxygen is determined by individual
physicians, rather than on the basis of a physiologic assessment. Published literature cites
acceptable saturation ranges from 88-98%.
This observational study was conducted to design and test a physiologic definition for
bronchopulmonary dysplasia at 36 weeks of life.
Infants were studied in a supine position with the pulse oximeter in position with good
signal prior to collecting baseline data. Feedings and medications were given 30 minutes
before the evaluation. Baseline data was collected on infant's current oxygen. Then, the
infants were weaned to room air for 30 minutes. If saturations remain ≥90%, the infant was
considered to have passed the oxygen reduction challenge (to NOT have BPD). The infant should
then be placed back in his/her baseline oxygen. If the infant has saturations <90% for 5
continuous minutes or <80% for 15 seconds, the infant should be immediately placed back in
his/her baseline oxygen, and the infant was considered to have NOT passed the challenge (to
have BPD).
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