Bronchopulmonary Disease Clinical Trial
Official title:
Nebulized Lignocaine for Topical Airway Anesthesia During Flexible Bronchoscopy: A Randomized Controlled Trial
Flexible bronchoscopy is one of the most widely performed procedures for diagnosis of various
bronchopulmonary diseases. Most patients tolerate the procedure well although cough is often
reported as a distressing symptom. It is likely that the acceptance of bronchoscopy would be
significantly improved with control of cough. Use of sedation during bronchoscopy has been
reported to improve procedure tolerance. However, awake(no sedation) bronchoscopy is
routinely performed at many centres including ours.
Topical lignocaine is administered during bronchoscopy for local anaesthesia. There is
limited literature on the efficacy of lignocaine delivered with the nebulized route during
awake flexible bronchoscopy. This study would help to determine the utility of nebulized
lignocaine in airway anaesthesia during flexible bronchoscopy.
For all patients meeting the inclusion criteria, the demographic profile including age, sex,
weight, smoking history and the type of procedures performed during bronchoscopy shall be
recorded. A written informed consent will be obtained from all participants. The patients who
undergo flexible bronchoscopy would be randomised in a one is to one ratio either to
nebulized lignocaine (4%) or saline (placebo) nebulization group. Prior to the bronchoscopy
blood pressure, pulse rate, respiratory rate and pulse oximetry saturation will be recorded
at the baseline Patients in both the groups shall be prepared in a similar fashion except for
the nebulized lignocaine. Patient, Operator, outcome assessor will be blinded to the
allocation.
During the procedure, 1.5ml aliquots of 1% lignocaine will be delivered through the
bronchoscope using spray-as-you go technique. The patients would be monitored for any adverse
effects throughout the procedure. The bronchoscopist doing the procedure will be provided 2
VAS charts to mark the severity of cough and overall procedure satisfaction.
Post procedure, patients will record the pain experienced while undergoing the procedure on
the faces pain rating scale.
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| Status | Clinical Trial | Phase | |
|---|---|---|---|
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