Chronic Obstructive Pulmonary Disease Clinical Trial
Official title:
A Randomized Controlled Trial to Study the Effect of Exercise Training Breathing Helium-Hyperoxia on The Exercise Tolerance and Quality of Life of Patients With Chronic Obstructive Pulmonary Disease
The purpose of this study is to examine whether breathing helium-hyperoxia during exercise in a pulmonary rehabilitation program can improve the exercise tolerance and health related quality of life of patients with Chronic Obstructive Pulmonary Disease (COPD).
It is well accepted that the exercise training as part of a comprehensive pulmonary
rehabilitation program can improve exercise tolerance, functional status and quality of life
in patients with COPD. It is feasible that if patients were able to perform a greater volume
or intensity of exercise during rehabilitation then the outcomes of the program would be
improved. Recent research has demonstrated that breathing a helium-hyperoxic gas mixture can
significantly reduce dynamic hyperinflation and dyspnea during exercise in patients with
COPD and can increase exercise tolerance to a greater extent than breathing room air or a
nitrogen-based hyperoxic gas. If patients with COPD were to breathe a helium-hyperoxic gas
during exercise they should be able to tolerate a greater intensity of exercise while
maintaining similar levels of exertional symptoms to those observed at lower exercise
intensities breathing room air. As a result patients randomized to the helium-hyperoxia
condition should obtain greater improvements in exercise tolerance than those receiving
usual care (i.e. breathing room air)
Comparisons: Standard pulmonary rehabilitation of patients with COPD receiving either usual
care (air breathing) or helium-hyperoxia (40% O2, 60% Helium).
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment
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