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Bronchiolitis in Infants Placebo Versus Epinephrine and Dexamethasone Study — BIPED  

Bronchiolitis Clinical Trial

Official title:
A Randomized Controlled Trial Comparing Epinephrine and Dexamethasone to Placebo in the Treatment of Infants With Bronchiolitis

Clinical Trial Summary

We hypothesize that infants with bronchiolitis treated with inhaled epinephrine in the Emergency Department (ED) and a 2-day course of oral dexamethasone will have fewer hospitalizations over 7 days compared to infants treated with placebo. To examine this hypothesis, we will conduct a phase III, multicentre, randomized, double-blind trial. Infants presenting to one of twelve study EDs will be enrolled to one of two study groups: (1) inhaled epinephrine and oral dexamethasone or (2) inhaled placebo and oral placebo. Our primary outcome will be admission for bronchiolitis by day 7 following the enrolment. As a planned secondary analysis, a between-group comparison of the primary outcome will be performed in those patients presenting with a first episode of bronchiolitis.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03567473
Study type Interventional
Source Children's Hospital of Eastern Ontario
Contact Kristina I Vogel
Phone 613-737-7600
Email kvogel@cheo.on.ca
Status Recruiting
Phase Phase 3
Start date December 13, 2018
Completion date June 30, 2025
View Details
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