TRANSPIRE: Lung Injury in a Longitudinal Cohort of Pediatric HSCT Patients

Status Recruiting

Clinical Trial Summary

Hematopoietic stem cell transplant (HSCT) is an effective but toxic therapy and pulmonary morbidity affects as many as 25% of children receiving transplant. Early pulmonary injury includes diffuse alveolar hemorrhage (DAH), thrombotic microangiopathy (TMA) interstitial pneumonitis (IPS) and infection, while later, bronchiolitis obliterans is a complication of chronic GVHD associated with severe morbidity and mortality. Improved diagnosis and treatment of pulmonary complications are urgently needed as survival after HSCT improves, and as HSCT is increasingly used for non-malignant disorders such as sickle cell disease. Currently, there are large and important gaps in the investigator's knowledge regarding incidence, etiology and optimal treatment of pulmonary complications. Moreover, young children unable to perform spirometry are often diagnosed late, and strategies for monitoring therapeutic response are limited. This is a prospective multi-institutional cohort study in pediatric patients undergoing allogeneic (alloHSCT) or autologous hematopoietic stem cell transplantation (autoHSCT). Assembly of a large prospective uniformly screened cohort of children receiving HSCT, together with collection of biological samples, will be an effective strategy to identify mechanisms of lung injury, test novel diagnostic strategies for earlier diagnosis, and novel treatments to reduce morbidity and mortality from lung injury after transplant.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Bronchiolitis
Bronchiolitis Obliterans
Bronchiolitis Obliterans Syndrome
Diffuse Alveolar Hemorrhage
Hematopoietic Stem Cell Transplant (HSCT)
Hemorrhage
Interstitial Pneumonitis
Lung Diseases, Interstitial
Lung Injury
Pneumonia
Thrombotic Microangiopathies

Clinical Trial Details

NCT number	NCT04098445
Study type	Observational
Source	Children's Hospital Medical Center, Cincinnati
Contact	Stephanie Edwards, BSN, RN
Phone	513-636-9292
Email	StephanieL.Edwards@cchmc.org
Status	Recruiting
Phase
Start date	September 8, 2021
Completion date	September 2036

View Details

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