Bronchiectasis Clinical Trial
Official title:
Prevalence of and Prognostic Impact of Bronchiectasis in COPD Patients
The identification of bronchiectasis in COPD has been defined as a different clinical COPD phenotype with greater symptomatic severity, more frequent chronic bronchial infection and exacerbations, and poor prognosis. A causal association has not yet been proven, but it is biologically plausible that COPD, and particularly the infective and exacerbator COPD phenotypes, could be the cause of bronchiectasis without any other known etiology, beyond any mere association or comorbidity.
The relationship between bronchiectasis and COPD has generated several questions. Is there any real increased prevalence of bronchiectasis in patients with COPD? Does the presence of bronchiectasis have an impact on the clinical characteristics, prognosis, or response to treatment in COPD, to the extent that it can be considered a distinct clinical phenotype? Should bronchiectasis in patients with COPD be seen as merely a comorbidity, or as a consequence of the disease's natural history? Is there a causal relationship between COPD and bronchiectasis? If this is the case, what are the pathophysiological mechanisms responsible for this relationship? And, finally, what is the role of chronic bronchial infection and exacerbations in this relationship? ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT05034900 -
Does Addition of Oscillatory Positive Expiratory Pressure (OPEP) Device to a Chest Physiotherapy Program Provide Further Health Benefits in Children With Bronchiectasis?
|
N/A | |
| Withdrawn |
NCT03376204 -
Pain Mechanisms in Patients With Bronchiectasis
|
||
| Completed |
NCT02550821 -
Comparison of Physical Activity Level Between Patients With Bronchiectasis and Healthy Subjects
|
||
| Completed |
NCT02656992 -
Effects of High Intensity Inspiratory Muscle Training on Exercise Capacity in Patients With Bronchiectasis
|
N/A | |
| Completed |
NCT01615484 -
Ex-vivo Perfusion and Ventilation of Lungs Recovered From Non-Heart-Beating Donors to Assess Transplant Suitability
|
N/A | |
| Completed |
NCT02048397 -
Pulmonary Rehabilitation Program (PRP) Versus PRP Plus Nutritional Supplementation in Patients With Bronchiectasis
|
N/A | |
| Completed |
NCT02282202 -
Evaluation of Oscillatory Positive Expiratory Pressure (oPEP) in Bronchiectasis and COPD
|
N/A | |
| Recruiting |
NCT01761214 -
Bacteriology and Inflammation in Bronchiectasis
|
N/A | |
| Recruiting |
NCT02527486 -
Seoul National University Airway Registry
|
N/A | |
| Completed |
NCT01578681 -
ELTGOL and Bronchiectasis. Respiratory Therapy
|
N/A | |
| Completed |
NCT01854788 -
3 Airway Clearance Techniques in Non Cystic Fibrosis Bronchiectasis
|
N/A | |
| Completed |
NCT00769119 -
A Phase II , Placebo-controlled Study to Assess Efficacy of 28 Day Oral AZD9668 in Patients With Bronchiectasis
|
Phase 2 | |
| Terminated |
NCT00524095 -
Bronchiectasis in Chronic Obstructive Pulmonary Disease (COPD) Patients: Role of Prophylaxis
|
Phase 2 | |
| Completed |
NCT01117493 -
Expert Patient Self-management Programme Versus Usual Care in Bronchiectasis
|
N/A | |
| Recruiting |
NCT00129350 -
Assessment of Heart and Heart-Lung Transplant Patient Outcomes Following Pulmonary Rehabilitation
|
Phase 1 | |
| Completed |
NCT00656721 -
Respiratory Mechanics Effects of Flutter Valve in Bronchiectasis Patients
|
N/A | |
| Completed |
NCT04081740 -
Biological Determinants of Sputum Rheology in Chronic Airway Diseases
|
||
| Enrolling by invitation |
NCT02546297 -
Comparisons of Inhaled LAMA or LAMA+LABA or ICS+LABA for COPD With Bronchiectasis
|
Phase 4 | |
| Completed |
NCT03628456 -
Effect of HFCWO Vests on Spirometry Measurements
|
N/A | |
| Completed |
NCT03750734 -
Target Validation and Discovery in Idiopathic Bronchiectasis
|