Bronchiectasis Clinical Trial
Official title:
Prevalence and Clinical Characteristics of Patients With Bronchiectasis With Comorbid Nontuberculous Mycobacteria Among Middle-aged and Old Women
The purpose of this study is to Understand the prevalence of non-tuberculous mycobacterial(NTM) infections in the middle-aged and old women patients with bronchiectasis in Mainland China, and explore the characteristics of patients with bronchiectasis comorbid NTM.
The development of bronchiectasis is closely related to chronic infection of pathogenic
microorganisms .Bronchiectasis and nontuberculous mycobacterial (NTM) infections are
inextricably linked Pathophysiologically. But the incidence rate and characteristics of NTM
infections among patients with bronchiectasis remains unclear in mainland China.
In this study, we will collect data of participants about demographic ,co-morbidities
,spirometry, mMRC score ,exacerbation history, QOL-B questionnaire, aetiology, spirometry ,
HRCT(or CT) scan ,results of microbiology samples and treatments, collect three consecutive
sputum(or induced sputum) samples to smear, bacteria culture, acid-fast stain, mycobacterium
cultivation and identification, drug susceptibility testing of nontuberculous mycobacteria.To
estimate the prevalance of non-tuberculous mycobacterial(NTM) infections in Middle-aged and
old women patients with bronchiectasis in northern China. To analyze clinical manifestations
and microbiological characteristics of patients with bronchiectasis comorbid NTM infections
By 16SRNA and gene sequencing.
In addition, A cross-sectional investigation about lung function and clinical data will be
done among patients who have confirmed bronchiectasis with NTM from February 2017 to December
2020.
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