Aetiology of Children With Bronchiectasis in China

Bronchiectasis Clinical Trial

Official title:

Aetiology of Children With Bronchiectasis in China--A Multicenter Retrospective Study

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT02555865
• Other study ID #: BCHlung002
• Status: Recruiting
• Phase: N/A
• First received: September 14, 2015
• Last updated: January 6, 2017
• Start date: June 2016
• Est. completion date: March 2022

Study information

• Verified date: January 2017
• Source: Beijing Children's Hospital
• Contact: Baoping Xu, MD,PhD
• Phone: 861059616308
• Email: xubaopingbch[@]163.com
• Is FDA regulated: No
• Health authority: China: Ministry of Science and TechnologyChina: Ethics Committee
• Study type: Observational

Clinical Trial Summary

This multicenter retrospective observation study is designed to investigate the etiology of children with bronchiectasis by review the medical records.

Description:

This study is divided into two parts. Part I. Retrospective review the 10 years medical records of the children with bronchiectasis from every center, and investigate the etiology of the cases by the standard diagnostic process. Part II. All new cases of bronchiectasis which was confirmed diagnosed at every center from the beginning of the study are made the investigation of the etiology by the standard diagnostic process.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 300
• Est. completion date: March 2022
• Est. primary completion date: March 2022
• Accepts healthy volunteers: No
• Gender: All
• Age group: N/A to 18 Years

Eligibility

Inclusion Criteria:A included patient must be coincident at least one point of the four items of HRCT manifestations.

• Internal bronchial diameter greater than the accompanying pulmonary artery.

• lack of bronchial tapering

• bronchi visible in the peripheral 1cm of lung

• bronchial diameter greater than adjacent segmental bronchi

Exclusion Criteria:Subject will be excluded if she or he has one of the following

• It is unable to provide complete medical records or the current condition can not accept the diagnosis process

• It does not agree to participate in the test

Study Design

Observational Model: Case-Only, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

• Bronchiectasis

Locations

Country	Name	City	State
China	Beijing Children'S Hospital	Beijing	Beijing

Sponsors (13)

Lead Sponsor

Collaborator

Beijing Children's Hospital

Children's Hospital of Changchun, Children's Hospital of Chongqing Medical University, First Affiliated Hospital of Guangxi Medical University, Jiangxi Province Children's Hospital, Shanghai Children's Medical Center, Shanxi Children's Hospital, Shenzhen Children's Hospital, The Affiliated Hospital Of Guizhou Medical University, The First Affiliated Hospital of Xiamen University, Tianjin Children's Hospital, Wuhan women and children's health care center, Yuying Children's Hospital of Wenzhou Medical University

Country where clinical trial is conducted

China, 

References & Publications (8)

Amorim A, Gracia Róldan J. Bronchiectasis: do we need aetiological investigation? Rev Port Pneumol. 2011 Jan-Feb;17(1):32-40. English, Portuguese. — View Citation

Barker AF. Bronchiectasis. N Engl J Med. 2002 May 2;346(18):1383-93. Review. — View Citation

Brower KS, Del Vecchio MT, Aronoff SC. The etiologies of non-CF bronchiectasis in childhood: a systematic review of 989 subjects. BMC Pediatr. 2014 Dec 10;14:4. doi: 10.1186/s12887-014-0299-y. Review. — View Citation

CHEN Jun, DUO Li-kun, WANG Xiao-feng. Clinical analysis of 22 children with bronchiectasis. J Clin Pediatr, 2012, 30(1):51-54.

Eastham KM, Fall AJ, Mitchell L, Spencer DA. The need to redefine non-cystic fibrosis bronchiectasis in childhood. Thorax. 2004 Apr;59(4):324-7. — View Citation

Gaillard EA, Carty H, Heaf D, Smyth RL. Reversible bronchial dilatation in children: comparison of serial high-resolution computer tomography scans of the lungs. Eur J Radiol. 2003 Sep;47(3):215-20. — View Citation

LIU Xiu-yun, JIANG Zai-fang. The etiology of ninety-one children with bronchiecatsis. J Clin Pediatr, 2011, 29(2):127-129.

WANG Hao,XU Bao-ping,LIU Xiu-yun,HU Ying-hui,REN Yi-xin,SHEN Kun-ling. Clinical characteristics and follow-up of bronchiectasis in children. Chinese Journal of Practical Pediatrics, 2014;29 (12):936-939.

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Number of participants with differential causes of bronchiectasis by reviewing the medical records or undergoing the standard diagnostic process	The cause of each paticipant with bronchiectasis will be recorded, for example post infection, PCD, PID, et al.	48 months	No