Bronchiectasis Clinical Trial
Official title:
Macrolide Mediates Pulmonary Infection of Pseudomonas Aeruginosa Via NLRC4 Inflammasome Signaling Pathway
It is acknowledged that IL-18, as a product of the inflammasome, is involved in host defence against viral and bacterial stimuli by modulating the immune response. The aim of this study was to determine IL-18 levels in serum of patients with Bronchiectasis and to investigate whether macrolide attenuate its levels.
Status | Completed |
Enrollment | 71 |
Est. completion date | January 2016 |
Est. primary completion date | January 2016 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 18 Years to 85 Years |
Eligibility |
Inclusion Criteria: 1. Able to provide written informed consent. 2. Confirmed diagnosis of bronchiectasis by HRCT. 3. Aged 18-85 years. Exclusion Criteria: 1. Bronchiectasis as a result of CF or active tuberculosis or non-tuberculous mycobacterial (NTM) infection. 2. Allergy to macrolide antibiotics 3. Any history of severe cardiopulmonary dysfunction, eg. left heart failure, Unstable cardiac arrhythmias 4. pregnant or nursing 5. hypogammaglobulinemia or other autoimmune disease 6. diagnosed with ABPA |
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
China | Shanghai Pulmonary Hospital | Shanghai | Shanghai |
Lead Sponsor | Collaborator |
---|---|
Jin-Fu Xu |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | IL-18 in plasma | after 3-5 days treatment of Azithromycin immediately | Yes |
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