Bronchiectasis Clinical Trial
Official title:
Sputum Clearance Effects of Hypertonic Saline in Non-cystic Fibrosis Bronchiectasis: a Randomized, Double-blind, Crossover Trial
This study aims to analyze whether the hypertonic saline nebulization enhances sputum clearance effects, reduces the impact on cough severity and their level of safety and tolerability in a population with non-cystic fibrosis bronchiectasis (NCFBE). In addition, this trial aims to compare these health outcomes among 3 nebulized solutions: hypertonic saline (7%); hyaluronic acid + hypertonic saline (7%); isotonic saline (0,9%).
The present study will be a randomized, double-blind, crossover trial. Each nebulized
solution [hypertonic saline (7%); hyaluronic acid + hypertonic saline (7%); isotonic saline
(0,9%)] will be administrated during 4 days. After each inhalation, all patients will carry
out a bronchial drainage session (autogenic drainage technique). All patients recruited will
perform the three arms of intervention. In this way, each patient will be able to act as
his/her own control.
A 7 days washout period will be required among the different solutions to avoid carryover
effects.
During the study period the patients' pharmacological treatment remained unchanged.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT05034900 -
Does Addition of Oscillatory Positive Expiratory Pressure (OPEP) Device to a Chest Physiotherapy Program Provide Further Health Benefits in Children With Bronchiectasis?
|
N/A | |
| Recruiting |
NCT04101448 -
Prevalence of Bronchiectasis in COPD Patients
|
||
| Withdrawn |
NCT03376204 -
Pain Mechanisms in Patients With Bronchiectasis
|
||
| Completed |
NCT02550821 -
Comparison of Physical Activity Level Between Patients With Bronchiectasis and Healthy Subjects
|
||
| Completed |
NCT02656992 -
Effects of High Intensity Inspiratory Muscle Training on Exercise Capacity in Patients With Bronchiectasis
|
N/A | |
| Completed |
NCT02282202 -
Evaluation of Oscillatory Positive Expiratory Pressure (oPEP) in Bronchiectasis and COPD
|
N/A | |
| Completed |
NCT01615484 -
Ex-vivo Perfusion and Ventilation of Lungs Recovered From Non-Heart-Beating Donors to Assess Transplant Suitability
|
N/A | |
| Completed |
NCT02048397 -
Pulmonary Rehabilitation Program (PRP) Versus PRP Plus Nutritional Supplementation in Patients With Bronchiectasis
|
N/A | |
| Recruiting |
NCT01761214 -
Bacteriology and Inflammation in Bronchiectasis
|
N/A | |
| Recruiting |
NCT02527486 -
Seoul National University Airway Registry
|
N/A | |
| Completed |
NCT01578681 -
ELTGOL and Bronchiectasis. Respiratory Therapy
|
N/A | |
| Completed |
NCT01854788 -
3 Airway Clearance Techniques in Non Cystic Fibrosis Bronchiectasis
|
N/A | |
| Completed |
NCT00769119 -
A Phase II , Placebo-controlled Study to Assess Efficacy of 28 Day Oral AZD9668 in Patients With Bronchiectasis
|
Phase 2 | |
| Completed |
NCT01117493 -
Expert Patient Self-management Programme Versus Usual Care in Bronchiectasis
|
N/A | |
| Terminated |
NCT00524095 -
Bronchiectasis in Chronic Obstructive Pulmonary Disease (COPD) Patients: Role of Prophylaxis
|
Phase 2 | |
| Recruiting |
NCT00129350 -
Assessment of Heart and Heart-Lung Transplant Patient Outcomes Following Pulmonary Rehabilitation
|
Phase 1 | |
| Completed |
NCT00656721 -
Respiratory Mechanics Effects of Flutter Valve in Bronchiectasis Patients
|
N/A | |
| Completed |
NCT04081740 -
Biological Determinants of Sputum Rheology in Chronic Airway Diseases
|
||
| Enrolling by invitation |
NCT02546297 -
Comparisons of Inhaled LAMA or LAMA+LABA or ICS+LABA for COPD With Bronchiectasis
|
Phase 4 | |
| Completed |
NCT03628456 -
Effect of HFCWO Vests on Spirometry Measurements
|
N/A |