Bronchiectasis Clinical Trial
Official title:
Study of the Effect of FLUTTER VRP1 in Patients With Bronchiectasis.
The research sought to assess the effects of Flutter ® VRP1 in patients with bronchiectasis.
Bronchiectasis is an airway disease with many etiologies characterized pathologically by the
abnormal permanent dilatation of bronchi, caused mainly by the perpetuation of inflammatory
processes induced by frequent episodes of bacterial infections, with consequent change in
the ciliated epithelial lining and compromising the effectiveness of mucociliary clearance
that can favor the hypersecretive state found in these patients.
In addition to drug therapy or surgical treatment, patients with bronchiectasis also have
physiotherapy, which is an important part in treatment. The patients present impaired mucus
transport, and can enjoy the benefits provided by respiratory therapy, which features
intended to increase the removal of airway secretions and thus reduce the obstruction to
improve ventilation and oxygenation.
One of the instruments commonly used in respiratory therapy is the Flutter ® VRP1 (VarioRaw
SA, Switzerland), which is a simple equipment, small, similar to a pipe that combines two
techniques: positive expiratory pressure (PEP) and high-frequency oscillations.
Some previous studies have shown beneficial effects after use of this device in patients
with bronchiectasis. However, it is unclear whether the mechanism of action is related to
the combination of PEP and the techniques of high frequency oscillation, or just one of
those components.
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Allocation: Randomized, Endpoint Classification: Safety Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
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