Bronchiectasis Adult Clinical Trial
Official title:
Characterization of Airway Mucus in Bronchiectasis Patients and Healthy Controls
Analysis of mucus, mucin and DNA concentration, MUC5B/5AC ratio, rheology, osmotic pressure, cohesion and nucleotides in sputum on 30 individual samples of good quality in healthy individuals and those with bronchiectasis. (60 total)
In this study the investigators will investigate the mucus properties in individuals with
idiopathic bronchiectasis and healthy individuals without a history of lung disease. In order
to understand how mucus is abnormal in disease conditions, the investigators need to
understand the mucus biochemical and biophysical properties in healthy individuals. In this
study the investigators will prospectively recruit patients with bronchiectasis and healthy
individuals from the community to provide airway sputum samples. In these samples the
investigators will measure an array of mucus properties. This will help our understanding of
the mucus-obstructive lung diseases and facilitate the development of appropriate and
effective disease prevention strategies.
A key question is whether mucus is hyper-concentrated and has abnormal biophysical properties
in individuals with mucus-obstructive lung disease. To answer this question, the
investigators need to understand the properties of the mucus in individuals with idiopathic
bronchiectasis and no history of lung disease. This study will allow us to collect airway
mucus (sputum) from individuals with bronchiectasis and healthy individuals with no history
of lung disease.
;
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT04142827 -
The Effect of Long Term Therapy With High Flow Humidification Compared to Usual Care in Patients With Bronchiectasis (BX)
|
N/A | |
Recruiting |
NCT06093191 -
Tobramycin Inhalation Solution for Pseudomonas Aeruginosa Eradication in Bronchiectasis
|
Phase 4 | |
Recruiting |
NCT06393257 -
Airway Clearance Technique of Oscillation and Lung Expansion in Bronchiectasis
|
N/A | |
Not yet recruiting |
NCT04509661 -
Efficacy and Safety of Inhaled Bronchodilator in Non-CF Bronchiectasis With Airflow Limitation
|
Phase 4 | |
Recruiting |
NCT06017739 -
Expiratory Flow Accelerator (Efa) vs Efa + High Flow in Chronic COPD and Bronchiectasis
|
N/A | |
Completed |
NCT04435327 -
Lung Damage Caused by SARS-CoV-2 Pneumonia (COVID-19)
|
||
Recruiting |
NCT03715322 -
Tobramycin in Bronchiectasis Colonized With Pseudmonas Aeruginosa
|
Phase 3 | |
Recruiting |
NCT03696290 -
Value of Inhaled Treatment With Aztreonam Lysine in Bronchiectasis
|
Phase 2 | |
Not yet recruiting |
NCT05068518 -
The Role of Airway Microbiota on Clinical Phenotypes and Disease Severity in Bronchiectasis
|
||
Recruiting |
NCT04658277 -
Effect of Long Term Clarithromycin for Prevention of Exacerbations in Non-cystic Fibrosis Bronchiectasis in Asian Populations
|
N/A | |
Completed |
NCT04744220 -
Evaluation of the Effect of Yoga Training on Functional Capacity and Quality of Life in Patients With Bronchiectasis
|
N/A | |
Completed |
NCT05764343 -
The Effect of Immediate Smoking Cessation Interventions for Smokers With Chronic Airway Diseases
|
N/A | |
Recruiting |
NCT05582798 -
Bronchiectasis Alpha-1 Augmentation Trial- Modulating Airway Neutrophil Function
|
Phase 4 | |
Not yet recruiting |
NCT04987827 -
Investigating the Clinical Features and Prognosis of Bronchiectasis Adult Patients
|
||
Recruiting |
NCT03791086 -
The BRIDGE Study - Bronchiectasis Research Involving Databases, Genomics and Endotyping
|
||
Completed |
NCT04234789 -
Predictors of Physical Activity Performance and Dynamic Hyperinflation in Patients With Bronchiectasis
|
N/A | |
Recruiting |
NCT04865861 -
The Characteristic of Airway Microbiome Profiling of COPD-bronchiectasis Overlap Patients and Its Association With Acute Exacerbation
|
||
Completed |
NCT04742270 -
Home Airway Clearance in Patients With Bronchiectasis (Home-Care Bronchiectasis)
|
N/A | |
Recruiting |
NCT05330637 -
Study on the Influence of Climatic and Environmental Factors on Respiratory Diseases in Sanya, Hainan Province, China.
|
||
Completed |
NCT05989360 -
The Utility of Lung Clearance Index in Ethnic Groups and in Disease
|
N/A |