Respiratory Muscles and Inspiratory Muscle Training

Breathing Exercises Clinical Trial

— IMT  

Official title:

Effects of Inspiratory Muscle Training on Respiratory Muscle Mechanics and Haemodynamics in Healthy Adults

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02243527
• Other study ID #: H14-00067
• Status: Completed
• Phase: N/A
• Start date: September 2014
• Est. completion date: July 2016

Study information

• Verified date: April 2019
• Source: University of British Columbia
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The effects of inspiratory muscle training (IMT) remain controversial. Many studies have examined the effect IMT has on exercise performance, but any changes to the body that come from IMT have yet to be looked at.

This study will look at how someone breathes can change after IMT. Understanding how IMT changes the body can help us use IMT in different treatments.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 25
• Est. completion date: July 2016
• Est. primary completion date: July 2016
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 19 Years to 39 Years

Eligibility

Inclusion Criteria:

• Recreationally active, 'Moderate' or 'High' category on International Physical Activity Questionnaire Short form questionnaire

• Able to read and understand English

• Pulmonary function within normal limits

Exclusion Criteria:

• History of or currently smoking

• History or current symptoms of cardiopulmonary disease (including asthma and exercise induced asthma)

• Currently participating and training in a sport at a provincial, national, or international level

• Ulcer or tumor in the esophagus, a nasal septum deviation, or recent nasopharyngeal surgery

• Allergies to latex or local anesthetic

• Contraindications to exercise testing

Related Conditions & MeSH terms

• Breathing Exercises
• Respiratory Muscles

Intervention

Other:
• Inspiratory Muscle Training
6-weeks of inspiratory muscle training
• Sham Inspiratory Muscle Training
A sham training procedure that is meant to elicit no physiologic changes

Locations

Country	Name	City	State
Canada	Centre for Heart Lung Innovation	Vancouver	British Columbia

Sponsors (2)

Lead Sponsor	Collaborator
University of British Columbia	Natural Sciences and Engineering Research Council, Canada

Country where clinical trial is conducted

Canada, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Dyspnoea	Using the modified Borg scale to assess changes in perceived dyspnoea after inspiratory muscle training.; The modified Borg scale is a 0-10 category ratio scale. The floor (0) of the scale is anchored subjectively to the subjects interpretation of "no breathing discomfort at all", and the ceiling (10) to represent "the most intense breathing discomfort they have experienced or could imagine experiencing".	Post-intervention - ie. immediately after 5 weeks of inspiratory muscle training
Other	Muscle Oxygenation	Using near-infrared spectroscopy to examine if there are any relative changes in concentration (?umol/Litre) of deoxygenated hemoglobin (HHb) after training. Deoxygenated hemoglobin is used as a surrogate of oxygen extraction specific to the local vasculature of the vastus lateralis,	Post-intervention - ie. immediately after 5 weeks of inspiratory muscle training
Primary	Diaphragm Electromyography	Using a multipair esophageal electrode catheter we will determine any changes to the electric activity of the diaphragm.; Diaphragm electromyography (EMG) has been expressed as %max. This unit is determined as the ratio of average EMG value (uV) divided by the maximal EMG activity (uV) generated during a maximal respiratory maneuver (inspiratory capacity during exercise).	Post Intervention - ie. immediately after 5 weeks of inspiratory muscle training
Secondary	Accessory Respiratory Muscle Activation	Using surface electromyography to determine the activation patterns of accessory respiratory muscles (scalene and sternocleidomastoid).; Data are expressed as %max. This value is determined by taking the average electromyography (EMG) activity divided by the maximal EMG activity generated during a maximal inspiratory maneuver (inspiratory capacity during exercise).	Post-intervention - ie. immediately after 5 weeks of inspiratory muscle training