Arterial Spin Labeling Perfusion Magnetic Resonance (MR) Imaging in Pediatric Brain Tumors

Brain Tumors Clinical Trial

Official title:

CHP-901:Arterial Spin Labeling Perfusion MR Imaging in Pediatric Brain Tumors

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00907244
• Other study ID #: CHP 901 ASL
• Secondary ID: 2008-4-5917
• Status: Completed
• Phase: N/A
• First received: May 20, 2009
• Last updated: October 26, 2012
• Start date: April 2008
• Est. completion date: July 2012

Study information

• Verified date: January 2012
• Source: Children's Hospital of Philadelphia
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Institutional Review Board
• Study type: Observational

Clinical Trial Summary

The purpose of this study is to get information regarding the usefulness and accuracy of this new magnetic resonance imaging (MRI) technique - termed arterial spin labeling (ASL) - in the diagnosis of pediatric brain tumors.

Description:

The purpose of this study is to get information regarding the usefulness and accuracy of this new MRI technique - termed arterial spin labeling (ASL) - in the diagnosis of pediatric brain tumors. This technique can non-invasively measure the blood flow to the brain during MRI examination. Because aggressive brain tumors require new blood vessels and a high level of blood supply to support its growth, we believe the tumor blood flow measured using ASL is a reliable indicator of tumor grade. This information may be useful for doctors to make treatment decisions and to monitor patients' response to treatment.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 13
• Est. completion date: July 2012
• Est. primary completion date: July 2012
• Accepts healthy volunteers: No
• Gender: Both
• Age group: N/A to 18 Years

Eligibility

Inclusion Criteria:

• Age 0-18 years

• Primary brain tumor (newly diagnosed or recurrent) with measurable disease (at least 1cm2)

Exclusion Criteria:

• Patients with cardiac pacemaker or ferrous metal foreign bodies

• Patients with medical problems contradictive to receiving MRI scans.

• Patients requiring general anesthesia or sedation for their MRI scan.

• Patients with a history of cerebrovascular disorders (stroke, moya moya) that may alter cerebral perfusion.

Study Design

Observational Model: Case-Only, Time Perspective: Prospective

Related Conditions & MeSH terms

• Brain Neoplasms
• Brain Tumors

Locations

Country	Name	City	State
United States	The Children's Hospital of Philadelphia	Philadelphia	Pennsylvania

Sponsors (2)

Lead Sponsor	Collaborator
Children's Hospital of Philadelphia	Thrasher Research Fund

Country where clinical trial is conducted

United States,