Brain Tumor Clinical Trial
Official title:
Cerebral Autoregulation and Carbon Dioxide Reactivity in Patients With Posterior Fossa Tumor
The normal cerebral blood flow is guided by factors such as cerebral autoregulation (CA) and
carbon dioxide reactivity (CO2R). Authors have demonstrated that CA and CO2R may be impaired
in presence of intracranial tumors.Most studies pertaining to assessment of CA and CO2R in
patients with brain tumors is limited to supratentorial tumors. Due to their anatomic
location, posterior fossa tumors result in obstruction of ventricular outflow, produce
hydrocephalus and features of raise intracranial pressure (ICP). It is possible that lesions
in the posterior fossa may affect CA and CO2R. It should also be noted that posterior fossa
surgeries are carried out in positions such as prone, lateral and sitting. Altered surgical
positions themselves affect systemic hemodynamics which may influence cerebral blood flow;
with presence of anesthetics further compromising the blood flow to the brain. Understanding
the homeostatic mechanisms of CA and CO2R may help in deciding proper positioning of
patients and maintenance of intraoperative hemodynamic.
The aim of this observational study was to evaluate CA and CO2R in patients with posterior
fossa tumor prior to surgical decompression of the lesion.
| Status | Not yet recruiting |
| Enrollment | 20 |
| Est. completion date | |
| Est. primary completion date | |
| Accepts healthy volunteers | No |
| Gender | Both |
| Age group | 18 Years to 60 Years |
| Eligibility |
Inclusion Criteria: - All patients with posterior fossa tumor - Scheduled for elective surgery - History of recent ventriculoperitoneal shunt (within 24 hours) Exclusion Criteria: - previous craniotomy - patients on ventilatory support - history of cerebrovascular accident - syncope or carotid artery disease - anemia - polycythemia - patients on vasoactive medications - those suffering from medical conditions such as diabetes mellitus and hypertension. |
Observational Model: Cohort, Time Perspective: Prospective
| Country | Name | City | State |
|---|---|---|---|
| India | All India Institute of Medical Sciences | New Delhi | Delhi |
| Lead Sponsor | Collaborator |
|---|---|
| All India Institute of Medical Sciences, New Delhi |
India,
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05023434 -
A Study to Measure the Effect of Brain Stimulation on Hand Strength and Function in Patients With Brain Tumors
|
||
| Completed |
NCT04474678 -
Quality Improvement Project - "My Logbook! - I Know my Way Around!"; ("Mein Logbuch - Ich Kenne Mich Aus!")
|
N/A | |
| Completed |
NCT02768389 -
Feasibility Trial of the Modified Atkins Diet and Bevacizumab for Recurrent Glioblastoma
|
Early Phase 1 | |
| Terminated |
NCT01902771 -
Dendritic Cell Vaccine Therapy With In Situ Maturation in Pediatric Brain Tumors
|
Phase 1 | |
| Recruiting |
NCT03175224 -
APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors
|
Phase 2 | |
| Recruiting |
NCT03286335 -
Local Control, Quality of Life and Toxicities in Adults With Benign or Indolent Brain Tumors Undergoing Proton Radiation Therapy
|
N/A | |
| Recruiting |
NCT05968053 -
Detection of Microplastics and Nanoplastics in Neurosurgery Patients (DT-MiNi)
|
||
| Recruiting |
NCT05358340 -
Dual Perfusion Imaging for Characterizing Vascular Architecture of Brain Lesions
|
N/A | |
| Recruiting |
NCT03276676 -
[18F]Fluciclovine and [18F]FLT PET/CT Assessment of Primary High-Grade Brain Tumors
|
Phase 2 | |
| Completed |
NCT02851355 -
Follow-up Survey of Patients Who Were Treated for Medulloblastoma or Primitive Neuroectodermal Tumors of the Central Nervous in Norway
|
||
| Completed |
NCT02409121 -
A Novel Health Information Technology System (BMT Roadmap) for Pediatric BMT Patients and Caregivers
|
N/A | |
| Completed |
NCT02558569 -
The Use of Fentanyl in General Anesthesia for Craniotomy With or Without 0.5% Levobupivacaine Scalp Block
|
Phase 4 | |
| Completed |
NCT02713087 -
Vasopressor Effects in Anesthetized Patients
|
Phase 4 | |
| Terminated |
NCT02674945 -
Understanding and Improving Quality of Life Through a Wireless Activity Tracker: Observational Phase
|
||
| Withdrawn |
NCT02165995 -
Use of Navigated Transcranial Magnetic Stimulation (nTMS) in Generated Motor and Language Mapping to Evaluate Brain Recovery Following Surgery
|
N/A | |
| Completed |
NCT01171469 -
Vaccination With Dendritic Cells Loaded With Brain Tumor Stem Cells for Progressive Malignant Brain Tumor
|
Phase 1 | |
| Withdrawn |
NCT01202539 -
Real-time Assessment of Frameless Intrafraction Motion
|
||
| Terminated |
NCT01044966 -
A Study of Intraventricular Liposomal Encapsulated Ara-C (DepoCyt) in Patients With Recurrent Glioblastoma
|
Phase 1/Phase 2 | |
| Completed |
NCT00760409 -
Differentiating Recurrent Brain Tumor Versus Radiation Injury Using MRI
|
N/A | |
| Completed |
NCT00503204 -
Phase I : Cediranib in Combination With Lomustine Chemotherapy in Recurrent Malignant Brain Tumour
|
Phase 1 |