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Radiation Induced Alterations in Resting State Brain Networks in Pediatric Brain Tumor Patients

Brain Tumor, Primary Clinical Trial

Official title:
Assessing Radiation Induced Alterations in Resting State Brain Networks in Pediatric Brain Tumor Patients

Clinical Trial Summary

With modern therapy, the survival rate for pediatric brain tumor patients has significantly improved, with over 70% of patients surviving their disease. However, this progress often comes at the cost of substantial morbidity, with cognitive deficits being the primary obstacle to independent living. Robust predictors of cognitive decline and a comprehensive understanding of the underlying mechanisms of cognitive injury remain elusive. This study will prospectively investigate alterations in brain resting state networks following radiation therapy using functional imaging. The hypothesis is that radiation therapy leads to dose-dependent alterations in functional connectivity in the networks associated with higher level cognition, ultimately leading to cognitive decline.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06185686
Study type Observational
Source Washington University School of Medicine
Contact Stephanie Perkins, M.D.
Phone 314-747-4405
Email sperkins@wustl.edu
Status Not yet recruiting
Phase
Start date April 30, 2024
Completion date April 30, 2027
View Details
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