Brain Neoplasms Clinical Trial
OBJECTIVES: I. Evaluate whether stereotactic radiosurgery provides local control at multiple
sites in patients with primary or metastatic brain tumors, controlled systemic disease, and
preserved neurologic function.
II. Examine survival, clinical outcome, and local tumor imaging response in these patients.
PROTOCOL OUTLINE: This is a randomized study. Tumor size and number are confirmed prior to
randomization. Patients are stratified by participating institution.
Patients are randomly assigned to 1 of 2 treatment groups. One group is treated with
fractionated whole-brain irradiation using megavoltage equipment.
The second group receives stereotactic radiosurgery plus fractionated whole-brain
radiotherapy. Stereotactic radiosurgery involves irradiation of all tumors to the margins on
stereotactic computerized tomography or magnetic resonance imaging. Either treatment may be
administered first; the second treatment begins within 1 month of the first.
Concurrent anticonvulsants and steroids are allowed. Patients are followed for change in
size and number of tumors at 1, 3, and 6 months; follow-up clinical exams are performed at
least every 2 months.
;
Allocation: Randomized, Primary Purpose: Treatment
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