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Brain Lesions clinical trials

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NCT ID: NCT03528200 Completed - Brain Lesions Clinical Trials

DYNA EMBOLIZATION - Pilot Study of IV Dyna CT and CBV Imaging Techniques

DynaEmbo
Start date: July 2015
Phase: N/A
Study type: Interventional

This is a prospective pilot study evaluating the efficacy of DynaCT in direct comparison to conventional catheter angiography in demonstrating the anatomic details of the vessels supplying brain lesions. Forty patients will be recruited for this pilot study.

NCT ID: NCT02559401 Completed - Brain Lesions Clinical Trials

Validation of Edema-invariant Multi-shell High Angular Resolution Diffusion Imaging (msHARDI)-Based Tractography With Intra-operative Cortical Stimulation

Start date: June 2014
Phase:
Study type: Observational

Currently, standard-of-care tractography is based on information obtained from diffusion tensor imaging (DTI). DTI is a diffusion magnetic resonance imaging (dMRI) technique that is routinely obtained on neurosurgical patients to assist in pre-operative planning. The primary objective of the proposed study is to determine the ability of msHARDI-based tractography to discern fibers in edematous brain regions.

NCT ID: NCT02328300 Withdrawn - Brain Metastases Clinical Trials

FLT PET/MR for Evaluation of Pseudoprogression in Patients With Brain Lesions

Start date: May 7, 2014
Phase:
Study type: Observational

This is a single arm, single center study of 15 patients with brain lesions being treated at UNC Hospitals. Subjects will undergo one (1) FLT-PET-MRI scan before their scheduled surgical biopsy of their brain lesion(s).

NCT ID: NCT02187822 Terminated - Brain Metastases Clinical Trials

Fractionated Stereotactic Radiotherapy (FSRT) in Treatment of Brain Metastases

Start date: October 9, 2014
Phase: Phase 1
Study type: Interventional

The main purpose of this study is to see whether addition of TPI 287 to FSRT is safe and tolerable. Researchers also want to find out if adding TPI 287 to FSRT can help with better controlling the growth of brain lesions in people with brain metastases from their cancer.

NCT ID: NCT01849549 Recruiting - Clinical trials for Cerebrovascular Disorders

Neuropsychological and Brain Medical Imaging Study in Patients With Brain Damage

CORAC
Start date: May 2013
Phase: N/A
Study type: Interventional

Two groups of subjects will be constitute: (i) patients with circumscribed brain injury (including stroke, vascular malformations, tumor or circumscribed infectious lesions) or degenerative disorders and selective cognitive disorders; (ii) healthy control subjects. The objective of this project is to evaluate specific neuropsychological deficits and apply current brain imaging techniques (anatomical, diffusion, functional) to patients suffering from these cognitive deficits due to brain damage, in order to elucidate the brain mechanisms underlying these deficits.

NCT ID: NCT01304576 Completed - Clinical trials for Cerebrovascular Disorders

Orientation Agnosia: Clinical and Anatomical Study

AGNORIENT
Start date: September 2010
Phase: N/A
Study type: Interventional

The area of the brain responsible of visuospatial processing data and more specifically the orientation of an object or image is located in parietal lobe, especially on the right side. A dysfunction of this region would result in a disorder of recognition of the orientation of objects and images that the investigators call orientation agnosia. Several isolated cases are reported in the literature but to the investigators knowledge deficit has never been systematically searched, or put into perspective compared to other neuropsychological deficits. Moreover, the precise location of the lesion responsible for such a disorder remains uncertain. The objectives of this study are (1) detect the existence of orientation agnosia in case of right parietal lesion, and (2) to improve the understanding of such a deficit allowing better management of this disorder.

NCT ID: NCT01254500 Recruiting - Brain Lesions Clinical Trials

To Investigate the Event Related Potentials (ERPs) of Patients With Brain Lesions

Start date: September 2010
Phase: N/A
Study type: Observational

Event-related potentials (ERPs)has the advantage of excellent temporal resolution on measuring real-time neural activities that reflect to higher level cognitive processes. A research project related to lesion studies in which patients with cognitive function impairment and communication disorder will be recruited as participants to examine their impairment as well as residual abilities by using ERPs. Hopefully, expected findings will provide further analysis based on the patterns of neural activities revealed by both patients and normal controls should be able to provide important evidence toward building the cross-linguistic theory. The findings also have applications on diagnostic and evaluation for patients with brain lesions for clinical application with communication disorder.

NCT ID: NCT00907530 Completed - Brain Lesions Clinical Trials

Study to Compare MultiHance With Gadovist in Magnetic Resonance Imaging (MRI) of the Brain

MERIT
Start date: September 2009
Phase: Phase 4
Study type: Interventional

This study is being conducted as a phase IV, double-blind, multi-center, randomized, crossover trial aimed at a within-subject comparison of MULTIHANCE and GADOVIST at a dose of 0.1 mmol/kg, in terms of qualitative and quantitative assessment of unenhanced MRI (UE MRI) and contrast-enhanced MRI (CE MRI) for the visualization of brain disease.