Brain and Cognitive Reserve

Brain Ischemia Clinical Trial

— BCN  

Official title:

Neuro-anatomical Correlates on Volumetric MRI on the Impact of Brain Reserve and Cognitive Reserve on Ischemic Strokes in Elderly

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02819167
• Other study ID #: 69HCL16_0151
• Status: Completed
• Phase: N/A
• First received: June 28, 2016
• Last updated: November 16, 2017
• Start date: May 26, 2016
• Est. completion date: August 2016

Study information

• Verified date: November 2017
• Source: Hospices Civils de Lyon
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Ischemic strokes are one of the leading causes of handicap and death in elderly people in France.

Cognitive reserve (CR) is an active model, defined as a function of lifetime intellectual activities and other environmental factors that explain differential susceptibility to functional impairment in the presence of pathology or other neurological insult. CR is estimated using variables for cognitive activity: years of education, professional status, socioeconomic status… Furthermore, brain reverse (BR) is a passive and quantitative model that depend on brain size and other quantitative aspects of the brain that explain differential susceptibility to functional impairment in the presence of pathology.

Firstly, volume and localization of ischemic strokes have a great impact on CR and BR due to brain injury. On the other hand, CR influences the severity and the expression of cognitive diseases.

The investigators realize a prospective study in order to assess the impact of CR and BR on cognitive prognosis after a right middle cerebral artery ischemic stroke in elderly patients.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 20
• Est. completion date: August 2016
• Est. primary completion date: August 2016
• Accepts healthy volunteers: No
• Gender: All
• Age group: 70 Years and older

Eligibility

Inclusion Criteria:

• =70 years old

• right middle cerebral artery ischemic stroke

• hospitalized in neurovascular unit of Pierre Wertheimer hospital between January 2015 to January 2016

Exclusion Criteria:

• Contraindication for MRI

• Hemorrhagic stroke

• Aphasia

Related Conditions & MeSH terms

• Brain Ischemia
• Ischemia

Intervention

Other:
• neurologic and neuropsychological evaluation
cognitive prognosis, cognitive reserve, brain volume will be studied on patients with scale, questionnaire, magnetic resonance imaging

Locations

Country	Name	City	State
France	Hôpital des Charpennes	Lyon

Sponsors (1)

Lead Sponsor	Collaborator
Hospices Civils de Lyon

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	evaluation of cognitive prognosis	measure will be performed with the Mattis dementia rating scale	one year post Ischemic stroke
Secondary	Volume of leucoencephalopathy	measure will be performed with a MRI	one year post Ischemic stroke
Secondary	volume of hippocampic	measure will be performed with a MRI	one year post Ischemic stroke
Secondary	brain injury	measure will be performed with a MRI	one year post Ischemic stroke
Secondary	volume of ischemic stroke	measure will be performed with a MRI	one year post Ischemic stroke
Secondary	evaluation of cognitive reserve	measure will be performed with the Cognitive reserve index questionnaire	one year post Ischemic stroke