Brain Ischemia Clinical Trial
Official title:
Prevention of Secondary Ischemia After Aneurysmal Subarachnoid Hemorrhage With Cerebrospinal Fluid Drainage. A Randomized Controlled Trial
In a prospective randomized controlled trial, the investigators aim to assess whether external lumbar drainage (ELD) of CSF is safe and reduces delayed cerebral ischemia and its sequelae in patients with an aneurysmal subarachnoid hemorrhage.
Delayed cerebral ischemia (DCI) is a frequent complication after an aneurysmal subarachnoid
hemorrhage (SAH). Its pathophysiological mechanism remains unclear but a role for cerebral
vasospasm and the presence of blood in the arachnoid space is likely. A wash out of blood
and blood breakdown products in the cerebrospinal fluid (CSF) could reduce the incidence of
vasospasm and DCI.
We aim to assess whether external lumbar drainage (ELD) of CSF is safe and reduces secondary
ischemia and its sequelae.
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Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Prevention
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