Metabolic Changes in the Activated Human Visual Cortex During Mild Hypoxia

Brain Hypoxia Clinical Trial

Official title: Metabolic Changes in the Activated Human Visual Cortex During Mild Hypoxia

Status Completed

Clinical Trial Summary

The primary objective of this research is to measure changes in neurochemical concentrations during stimulation of the primary visual cortex, in both conditions of normoxia (normal oxygen availability) and induced mild hypoxia (reduced oxygen availability).

Clinical Trial Description

The goal is to determine the effect of mild hypoxia on human brain energy metabolism of healthy young adult subjects. For this purpose, the Investigator will utilize non-invasive imaging modalities based on functional magnetic resonance spectroscopy (fMRS) to estimate metabolic changes during a visual stimulus, while subjects are exposed to well-controlled gas mixtures that resembles conditions of either normoxia or mild hypoxia. Identifying the impact of mild hypoxia on functional brain energy metabolism in the healthy human brain is a crucial step for generating hypotheses in multiple patient populations that experience mild hypoxia as consequence of their pathological condition, such as in sleep apnea and traumatic brain injury. The Investigator hypothesize that the energetic demands of neuronal activation as revealed by fMRS will not be affected by mild hypoxia. ;

Related Conditions & MeSH terms

• Brain Hypoxia
• Hypoxia
• Hypoxia, Brain

• NCT number: NCT02482571
• Study type: Interventional
• Source: University of Minnesota - Clinical and Translational Science Institute
• Status: Completed
• Phase: N/A
• Start date: August 13, 2015
• Completion date: September 26, 2016