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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT02331901
Other study ID # mtbi-1
Secondary ID
Status Completed
Phase N/A
First received December 23, 2014
Last updated October 24, 2016
Start date December 2014
Est. completion date September 2016

Study information

Verified date October 2016
Source University of Aarhus
Contact n/a
Is FDA regulated No
Health authority Denmark: The Regional Committee on Biomedical Research Ethics
Study type Observational

Clinical Trial Summary

This study examine the possible microstructural changes in the middle brain after mTBI using diffusion MRI


Description:

There is a need for clinical and biological markers at 2-3 month to screen people in risk of getting chronic post-concussion symptoms (PCS) but also biomarkers in the brain to find out if this group with prolonged symptoms has measurable changes in the brain which could explain the persisting symptoms.

Several biomarkers and brain areas have been investigated as possible sites of injury after mild traumatic brain injury (mTBI). The nature of the diffuse PCS makes corpus callosum (CC), thalamus (THA) and hippocampus (HIP) interesting because of their central position and connection to widespread motor, sensory and cognitive processes and other brain areas.

In most prior studies conventional magnetic resonance imaging (MRI) has failed to detect pathology especially in the later phase. Diffusional Kurtosis Imaging (DKI) and Diffusional Tensor Imaging (DTI) are more sensitive to microstructural changes and might serve as biomarkers in the middle brain after mTBI.

It is hypothesized that there will be a difference in the microstructure of the thalamus, corpus callosum and hippo campus as measured with DKI between two groups of mTBI subjects with and without PCS. Secondary it is hypothesized that DKI are more sensitive than DTI in the measure of microstructural changes.


Recruitment information / eligibility

Status Completed
Enrollment 50
Est. completion date September 2016
Est. primary completion date September 2016
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Both
Age group 18 Years to 30 Years
Eligibility Inclusion Criteria:

- Concussion caused by a head trauma according to the diagnostic criteria recommended by the Danish Consensus Report on Commotio Cerebri within the last 2-5 months. The criteria are based recommendations by the WHO Task Force, but with the amendment, that there must have been a direct contact between the head and an object in order to rule out acceleration - deceleration traumas.

- Age 18 to 30 years at the time of the head trauma.

- Able to understand, speak and read Danish.

- Patients with symptoms at least three items on the Rivermead Post Concussion Symptoms Questionnaire (RPQ) rated as moderate or severe problem. PCS have to be subjectively rated as causing substantial impairment in daily life. Patients with out symptoms (controls) having no problems on the RPQ.

Exclusion Criteria:

- 1. Objective neurological findings from neurological examination and / or acute trauma CT scan, indicating neurological disease or brain damage.

- Previous concussion leading to persistent PCS within the last two years.

- Severe misuse of alcohol, prescription drugs and / or illegal drugs.

- Psychiatric morbidity or severe neurological disease that impedes participation in the treatment, i.e. Bipolar Disorder, autism, psychotic disorder (life time), multiple sclerosis etc..

- Suitable for MRI examination

Study Design

Observational Model: Case Control, Time Perspective: Cross-Sectional


Related Conditions & MeSH terms


Locations

Country Name City State
Denmark Region Hospital Hammel Neurocenter Hammel

Sponsors (1)

Lead Sponsor Collaborator
University of Aarhus

Country where clinical trial is conducted

Denmark, 

Outcome

Type Measure Description Time frame Safety issue
Other Symptoms Questionnaire 2-5 month after mTBI No
Other Cognitive performance Interview and computer test 2-5 month after mTBI No
Primary Diffusion kurtosis Imaging (DKI) MRI measurement unit 2-5 month after mTBI No
Secondary Diffusion Tensor Imaging (DTI) MRI measurement unit 2-5 month after mTBI No
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