Brain Calcification Clinical Trial
Official title:
A Registered Cohort Study on Brain Calcification
Brain calcification is a common neuroimaging feature in patients with metabolic, neurological, or developmental disorders, infectious diseases, traumatic or toxic history, as well as in otherwise normal older people. To understand the clinical and genetic characteristics of brain calcification, we establish a cohort of brain calcification to follow up patients with brain calcification.
| Status | Recruiting |
| Enrollment | 2000 |
| Est. completion date | December 31, 2079 |
| Est. primary completion date | December 31, 2029 |
| Accepts healthy volunteers | Accepts Healthy Volunteers |
| Gender | All |
| Age group | N/A and older |
| Eligibility |
Inclusion Criteria: - Patients with brain calcium deposit(s) based on examinations of CT scans - Patients with total calcification score(TCS) greater than the physiological threshold - Relatives of brain calcification patients. - Unrelated healthy controls - Participants or Parent(s)/legal guardian(s) willing and able to complete the informed consent process Exclusion Criteria: - Brain calcification caused by specific secondary factors such as infection, poisoning, and trauma - Participants declining or unable to comply with trial procedures and visit schedule |
| Country | Name | City | State |
|---|---|---|---|
| China | Department of Neurology, First Affiliated Hospital Fujian Medical University | Fuzhou | Fujian |
| Lead Sponsor | Collaborator |
|---|---|
| Wan-Jin Chen | Chang Gung Memorial Hospital, Taipei Veterans General Hospital, Taiwan |
China,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | The incidence of hereditary brain calcification | Look for the causative gene in the patient with brian calcification | Up to 20 years |