Brachial Plexus Injury Clinical Trial
Official title:
Changes in Optic Nerve Sheath Diameter in Response to Various Levels of End Tidal Carbon Dioxide Levels in Healthy Patients Under General Anaesthesia
Intracranial Pressure ( ICP ) monitoring is an essential component of traumatic brain
injured ( TBI ) patients management. The clinical signs of raised ICP may be unreliable and
may reflect relatively late cerebral decompensation. ICP may be monitored by invasive or non
invasive techniques. While invasive techniques show the real time values of ICP, they are
associated with many complications like, intracranial bleeding and infection, occlusion of
the catheter tip by blood, debris and difficult to locate ventricle in presence of cerebral
oedema. All these drawbacks of invasive methods can be averted by employing non invasive
techniques of ICP monitoring. Although they do not show a real time value but are excellent
tools to detect presence or absence of raised ICP. Elevated ICP can be detected by
Computarised tomographic scan (CT) or Magnetic resonance imaging (MRI) but , these
techniques are time consuming and require transportation of a patients who may be unstable
.The quick and non invasive nature of ultrasonography is fast becoming popular for rapid
detection of elevated ICP at bedside in emergency and ICU by monitoring the optic nerve
sheath diameter ( ONSD ). Its limitations notwithstanding, ultrasonographic ONSD monitoring
is likely to be more reliable than clinical assessment in the diagnosis of intracranial
hypertension especially, when patient is under sedation which precludes proper clinical
examination. Therefore, in recent years ,among non invasive methods, bedside ocular
ultrasonography to monitor ICP has gained popularity.
Carbon dioxide being a potent modulator of cerebral vascular tone, alters the ICP by
changing the size of cerebral vasculature and thereby, cerebral blood flow (CBF) and this
action occurs very rapidly, over e period of few minutes. In a range of PaCO2 20mmHg to 80
mmHg the cerebral blood flow changes in a linear manner. End tidal carbon dioxide
concentration(EtCO2) is a surrogate measure of PaCO2 (especially in a haemodyanimically
stable patient with healthy lungs ) and is routinely monitored continuously in patients
subjected to general anaesthesia. To date there is very little literature on the effects
changing EtCO2 on ONSD . This prompted us to conduct this study to find out the effects of
different levels of EtCO2 on ONSD.
In this study we monitored the effect of three different EtCO2 levels ( 40mmHg,30mmHg and
50mmHg ). In these healthy patients we observed rapid response in ONSD with changes in
EtCO2. This again highlights the fact that optic nerve being in direct communication with
the brain ,the pressure changes in the latter are reflected in the ONSD. The alteration in
ONSD was immediate in response to EtCO2 changes, and moreover,changes in ONSD were parallel
to the EtCO2 changes. Since CBF and cerebral blood volume change in response to changes in
PaCO2, the ONSD also changes accordingly. Over the years ,advancements in monitoring of ICP
has enabled the diagnosis of elevated ICP reliably by non-invasive techniques.Optic nerve
sheath diameter measurement using bedside ultrasound has been shown to correlate with
clinical and radiologic signs and symptoms of raised ICP. Despite the association between
ONSD and PaCO2 , there is scanty literature on ONSD responsiveness to a more dynamic
surrogate of PaCO2, that is EtCO2. The pertinent advantages of EtCO2 over PaCO2 measurement
is that the former is continuously monitored under anesthesia and avoids time consuming
process of arterial blood gas sampling. Moreover, the sensitivity of ICP to even small
fluctuations in EtCO2 has been reported in literature. Animal studies have estimated that
the rate of this increase in ONSD by 0.0034mm/mmHg increase in ICP.
The ONSD was smallest (0.29cm) at EtCO2 30mmHg, and biggest (0.40cm ) at EtCO2 50mmHg while
it was intermediate ( 0.34cm) at EtCO2 40 mmHg. These changes in ONSD are direct
representation of changes in ICP brought about by changes in CBF due to PaCO2 changes. Based
on results of Bland Altman plots, the calculated 95% confidence interval (CI) for the
difference of two measures( EtCO2 40mmHg and 30mmHg ) on ONSD was 0. 009 to 0.102 and the
calculated CI for the difference of other two measures ( EtCO2 40mmHg and 50mmHg ) on ONSD
was 0.152 to 0. 29 and thus were observed to be statistically insignificant.
Recently Kim et al studied ONSD responsiveness to two levels of EtCO2 ,40 and 50mmHg, each
measured at 1 and 5min and they observed significant changes in the diameter of ONSD. Thus
their results are at variance with our study. Various possibly reasons for differences in
findings are Kim et al studied a small number of patients as opposed to a relatively larger
sample size in our study. Also they used total intravenous anesthesia combining propofol and
remifentanil infusion. This combination is more likely to predispose patients to systemic
hypotension which in turn would increase ICP by causing cerebral vasodilation. Other
possibility for different results may be that sonographic measurements of ONSD may vary by
the observer's skills or even type of ultrasound device.
According to available literature, the upper limit of ONSD used to define ICP more than
20mmHg (raised ICP ) ranges from 0.48 to 0.57 cm. In our study ,the upper limit of ONSD at
EtCO2 level 50mmHg was average of 0.40cm which implies that even at EtCO2 50mmHg,
intracranial hypertension is a remote possibility in healthy non-neurosurgical patients with
normal brain compliance. We kept constant the factors such as position of patients, time of
measurement after achieving target EtCO2, measuring ONSD in a single plain ( transverse) and
involving same experienced operator,,thereby, avoiding any confounding factors.
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Observational Model: Case-Crossover, Time Perspective: Prospective
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