BPD Clinical Trial
Official title:
Effect of Autologous Cord Blood Mononuclear Cells for Treatment of Bronchopulmonary Dysplasia in Extremely Preterm Neonates: a Non-Randomized Case-Control Trial Study
This is a non-randomized, case-controlled trial that evaluates the efficacy of autologous cord blood mononuclear cells(ACBMNC) infusion as a Treatment for BPD. The results of this trial will provide valuable clinical evidence for recommendations on the treatment of BPD in extremely preterm infants. Informed consent before birth is signed. In this prospective clinical trial, preterm neonates less than 28 weeks who previously stored ACBMNC and then suffer BPD will be assigned to be ACBMNC infusion group, while those who do not previously stored ACBMNC or then refuse ACBMNC infusion and suffer BPD will be assigned to be control group. In the ACBMNC infusion group, when BPD occurred, the pre-stored ACBMNC will be removed and rewarmed, and then ACBMNC(5×107 cells /kg) will be intravenously injected within 24 hours. The control group receives standardized treatment without special treatment. The total number of participants is 76 and the same in both groups. The primary outcome is the rate of mortality or ratio of severe BPD at 36 weeks of postmenstrual age or discharge home. The secondary outcomes will include other common preterm complication rate and the number of hospitalizations due to pneumonia within 1 year of postmenstrual age.
Status | Not yet recruiting |
Enrollment | 76 |
Est. completion date | September 30, 2023 |
Est. primary completion date | March 31, 2023 |
Accepts healthy volunteers | No |
Gender | All |
Age group | N/A to 28 Weeks |
Eligibility | Inclusion Criteria: - 1.born at study hospital; - 2. singleton birth; - 3. less than 28 weeks GA - 4.Signed informed consent obtained; - 5. Umbilical cord blood collection and testing qualified; 6.Diagnosed with BPD Exclusion Criteria: - 1. with severe congenital abnormalities; - 2.with maternal clinical chorioamnionitis - 3. the mother was positive for hepatitis B (HBsAg and/or HBeAg) or C virus (anti-HCV), syphilis, HIV (anti-HIV-1 and -2) or IgM against cytomegalovirus, rubella, toxoplasma and herpes simplex virus. |
Country | Name | City | State |
---|---|---|---|
China | Ren Xuejun | Dongguan | Guangdong |
China | Jie Yang | Guangzhou | Guangdong |
Lead Sponsor | Collaborator |
---|---|
Guangdong Women and Children Hospital |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Rate of mortality or ratio of severe BPD | Rate of mortality or ratio of severe BPD at discharge or corrected gestational age at 36 weeks | 36 weeks of postmenstrual age or discharge home whichever comes first. | |
Secondary | Incidence of other preterm complications | Incidence of other preterm complications including intraventricular hemorrhage (IVH), periventricular leukomalacia(PVL), necrotizing enterocolitis (NEC), retinopathy of prematurity (ROP), ventilation-associated pneumonia (VAP) and late onset sepsis (LOS) | 36 weeks of postmenstrual age or the discharge home whichever comes first. | |
Secondary | The number of hospitalizations | To compare the number of hospitalizations due to pneumonia, wheezing, asthma, nighttime cough, need for oxygen therapy, height, weight, nervous system development within 1 or 2 year of postmenstrual age.
Long-term outcome. |
1 or 2 year of postmenstrual age |
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---|---|---|---|
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