Clinical Trial Details
— Status: Completed
Administrative data
| NCT number |
NCT04579731 |
| Other study ID # |
2008-133-1150 |
| Secondary ID |
|
| Status |
Completed |
| Phase |
|
| First received |
|
| Last updated |
|
| Start date |
August 25, 2020 |
| Est. completion date |
June 2, 2021 |
Study information
| Verified date |
August 2021 |
| Source |
Seoul National University Hospital |
| Contact |
n/a |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Observational
|
Clinical Trial Summary
The role of bowel bladder disorder, or BBD, has been highlighted as a major player in
vesicoureteral reflux and urinary tract infection (UTI). However, the diagnosis of BBD are
still conceptual and subjective, because of the diagnosis of constipation, main
pathophysiology in BBD has not been established well.
Description:
Functional constipation is a common disorder among children, accounting for 3-5% of visits to
pediatric clinics and even 10% to 25% of consultation for pediatric gastroenterologists. It
could cause recurrent abdominal pain, stool retention as well as fecal incontinence. In the
urologic field, this is known to develop urinary symptoms. Constipation has been associated
with voiding dysfunction and urinary tract infection in children. It is assumed that impacted
stool in distal rectum mechanically affect the bladder leading to detrusor overactivity.
Additionally, impacted stool would elevate the uretheral sphincter tone, having patients void
with incomplete sphincter relaxation and eliciting dysfunctional voiding. Stool impaction may
be the source of bacteria causing urinary tract infection and led to recurrent bacteriuria.
Treatment of constipation by itself is quite effective alleviating urologic symptoms in as
much as two-third of the patients.
The role of constipation has been highlighted as a major player in vesicoureteral reflux and
urinary tract infection (UTI). The presence of bowel bladder disorder (BBD) was associated
with higher risk of breakthrough infection and a lack of spontaneous resolution. Although
constipation is the major player in BBC, there is any objective standard regarding the
diagnosis and treatment of constipation. Given the high prevalence and morbidity of children
affected by UTI or VUR in relations to BBD, it is imperative that diagnostic and treatment
methods are developed.
Despite the known implication of constipation, the diagnosis of constipation may be
problematic due to a lack of standard definition for this condition. This may be due to
different views between clinicians about which aspect are most crucial for diagnosing
constipation. Some underline the subjective nature such as infrequent or difficult
defecation, other stress the quality of stool, still others were in search of objective
criteria of constipation, like the amount of impacted stool or colonic transit time.
Consequently, various criteria have been reported.
The lack of standard criteria for constipation causes trouble sometimes in making a proper
decision for diagnosis, intervention, follow-up, and discharge of treatment.
