Bone Resorption Clinical Trial
Official title:
Effect of Citric Acid Demineralization on Autogenous Bone Blocks Consolidation in Humans: Qualitative, Quantitative and Immunohistochemical Analysis
NCT number | NCT03357068 |
Other study ID # | FOBblock |
Secondary ID | |
Status | Completed |
Phase | N/A |
First received | |
Last updated | |
Start date | July 1, 2017 |
Est. completion date | December 22, 2018 |
Verified date | February 2023 |
Source | University of Sao Paulo |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
This study evaluates the effect of citric acid demineralization in autogenous bone blocks consolidation. Half of participants will receive citric acid treatment at the bone block and recipient site. Other half will receive no demineralization treatment.
Status | Completed |
Enrollment | 10 |
Est. completion date | December 22, 2018 |
Est. primary completion date | July 30, 2018 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 65 Years |
Eligibility | Inclusion Criteria: - Presence of atrophic anterior maxilla (width 1.5 to 4 mm) - Absence of active periodontal disease. - Enough bone width on donor sites (oblique line or ment) Exclusion Criteria: - Systemic disease that impede surgical procedure as blood diseases, endocrine diseases, impaired coagulation - Smokers - Pregnant women - Patients receiving radiotherapy or chemotherapy - Patients using bisphosphonates |
Country | Name | City | State |
---|---|---|---|
Brazil | Bauru School of Dentistry | Bauru | Sao Paulo |
Lead Sponsor | Collaborator |
---|---|
University of Sao Paulo |
Brazil,
Rezende ML, Consolaro A, Sant'Ana AC, Damante CA, Greghi SL, Passanezi E. Demineralization of the contacting surfaces in autologous onlay bone grafts improves bone formation and bone consolidation. J Periodontol. 2014 May;85(5):e121-9. doi: 10.1902/jop.2013.130298. Epub 2013 Oct 30. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Clinical bone block consolidation | Absence of fibrous tissue by clinical observation | 5 months | |
Primary | Computerized tomography images bone block consolidation | Absence of images compatible to fibrosis in cone beam computerized tomography images | 5 months | |
Primary | Histological bone block consolidation | Absence of fibrous tissue between bone block and recipient site in histological images. | 5 months | |
Secondary | Bone width | Measurement of bone width in mm on cone beam computerized tomography. Ideal if >6 mm. | 5 months |
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT04073654 -
SA Versus SOI Surfaces for Single Implant-supported Crown
|
N/A | |
Recruiting |
NCT06374342 -
BONE SUBSTITUTES OUTCOMES
|
||
Not yet recruiting |
NCT04345250 -
Bone Response to Exercise and Energy Restriction in Young Adults
|
N/A | |
Completed |
NCT05533502 -
Combination Plant-Based Protein and Marine-Based Multi-Mineral Supplement and Bone Remodeling in Young Adults
|
N/A | |
Completed |
NCT04279392 -
Healthy Body, Healthy Bones After Bariatric Surgery Trial
|
Phase 1/Phase 2 | |
Recruiting |
NCT04548258 -
Bone Changes Assessment in Screw-Retained Maxillary Complete Denture With Electric Welded Framework Versus Cast One
|
N/A | |
Withdrawn |
NCT04331028 -
Effect of Shock-wave Therapy on the Resorption and Bone Formation in Maxillary Postextraction Sockets
|
N/A | |
Completed |
NCT06383117 -
Understanding Effects of Calcium on the Gut-Bone Axis
|
N/A | |
Recruiting |
NCT06334159 -
Guided Bone Regeneration Using Fixed vs Non-Fixed Resorbable Collagen Membranes
|
N/A | |
Completed |
NCT03888339 -
Influence of Abutment Shape on Peri-implant Marginal Bone Loss
|
N/A | |
Completed |
NCT03026894 -
Association of Force Distribution and Bone Resorption
|
N/A | |
Completed |
NCT02470611 -
Sodium Alendronate in Non Surgical Periodontal Therapy
|
Phase 4 | |
Completed |
NCT00297830 -
Zoledronic Acid Versus Alendronate for Prevention of Bone Loss After Organ Transplantation
|
Phase 2/Phase 3 | |
Recruiting |
NCT03431766 -
0.2% Chx Gel vs Implant Bacterial Contamination
|
N/A | |
Recruiting |
NCT04141215 -
Allogeneic Bone Paste Versus Allogeneic Bone Powder
|
N/A | |
Recruiting |
NCT05018130 -
Bio-Integrative Versus Metallic Screws for Calcaneus Osteotomies
|
N/A | |
Completed |
NCT04790019 -
The Effects of Low Energy Availability and High Impact Jumping on Markers of Bone (re)Modelling in Females
|
N/A | |
Recruiting |
NCT03889587 -
Innervation of Vascularized Iliac Transplant Avoids Resorption in Jaw Bone Reconstruction
|
N/A | |
Completed |
NCT05804604 -
Bone Intake Proteins and Muscle Mass Deficiency in Proximal Femur Fractures
|
||
Terminated |
NCT03089619 -
Alveolar Management Following Teeth Extraction
|
Phase 4 |