Loratadine for Improvement of Bone Pain in Patients With Chronic

Clinical Trial Summary

G-CSF causes a release of histamine that may be a cause of chronic bone pain. Loratadine targets histamine, and so may be effective in reducing bone pain.The researchers plan to prospectively assess the effectiveness of loratadine for chronic bone pain in patients with chronic G-CSF use.

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05841186` - Correlation of Timing of Pegfilgrastim Administration and PIBP.	N/A
Recruiting	`NCT03858205` - Low-Dose Radiotherapy in Treating Painful Bone Metastases in Patients With Multiple Myeloma	N/A
Active, not recruiting	`NCT03529565` - Histamine and Bone Pain Association in Participants With Breast Cancer Metastatic in the Bone

See also

Status

Clinical Trial

Phase

Recruiting

NCT05841186 - Correlation of Timing of Pegfilgrastim Administration and PIBP.

N/A

Recruiting

NCT03858205 - Low-Dose Radiotherapy in Treating Painful Bone Metastases in Patients With Multiple Myeloma

N/A

Active, not recruiting

NCT03529565 - Histamine and Bone Pain Association in Participants With Breast Cancer Metastatic in the Bone

Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.

Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.

Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

NCT number	NCT03883386
Study type	Interventional
Source	University of Michigan
Contact
Status	Terminated
Phase	Phase 2
Start date	June 24, 2019
Completion date	October 18, 2019

Loratadine for Improvement of Bone Pain in Patients With Chronic Granulocyte-Colony Stimulating Factor (G-CSF) Use

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms