Clinical Trials Logo
  1. Home
  2. Bone Marrow
  3. NCT03793530

Autologous Bone Marrow Concentrate in Elective Tranforaminal Lumbar Interbody Fusion Surgery

Spinal Fusion Clinical Trial

Official title:
The Use of Bone Marrow Concentrate in Elective Tranforaminal Lumbar Interbody Fusion Surgery: A Randomized Control Trial

Clinical Trial Summary

This study aims to evaluate the effect of bone marrow concentration on bone healing and spinal fusion by comparing clinical and imaging outcomes between patients receiving transforaminal lumbar intebody fusion with local bone graft and with intraoperative bone marrow concentration and those receiving transforaminal lumbar intebody fusion with local bone graft only.

Clinical Trial Description

Spinal arthrodesis has become the mainstay of treatment for severe spinal deformity, spinal instability, spondylolisthesis, and symptomatic degenerative disease. Its primary goal is to develop an osseous bridge between adjacent motion segments to prevent motion, relieve pain, and facilitate neurological recovery. One of the arthrodesis method is transforaminal lumbar intebody fusion. After removal of the problematic disc, iliac crest bone graft was harvested and impacted into the space with cage to facilitate fusion. However, patients are exposed to additional risk of harvesting site, such as pain, infection, wound healing problem or hematomas. Local bone graft harvested from decompression is one of the alternative solutions to avoid these complications. However, the effect of local boen graft is inferior to iliac crest bone graft because iliac crest bone graft contains three important ingredients for successful fusion: osteoconductive scaffold, osteoinductive factors, and the ability to osteogenesis. Mesenchymal stem cells (MSCs) are pluripotent cells that can differentiate into multiple mesenchymal tissues, including tenocytes, chondrocytes and osteoblasts, as well as being a source of multiple growth factors to establish an environment conducive to soft and hard tissue regeneration. As bone marrow concentration has high concentration of mesenchymal stem cells, some studies have shown that autologous bone marrow concentration can improve bone healing. In this study, we will add bone marrow concentration into local bone graft during transforaminal lumbar intebody fusion and evaluate the effect of bone marrow concentration on bone healing and spinal fusion. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03793530
Study type Interventional
Source Show Chwan Memorial Hospital
Contact Ming-Hsien Hu, MD
Phone +886-975611289
Email minghsienhu@gmail.com
Status Recruiting
Phase N/A
Start date August 1, 2017
Completion date December 2020
View Details
See also
  Status Clinical Trial Phase
Completed NCT04037059 - Impact of Body Habitus (Arm Span and Abdominal Girth) on Activities of Daily Living (ADL)
Recruiting NCT03883022 - Vancomycin Powder Combined With Autogenous Bone Graft as a Prevention for Post-operative Infection for Spine Surgery N/A
Not yet recruiting NCT06003010 - Yoga for Adolescent Idiopathic Scoliosis (AIS) Patients N/A
Completed NCT01136590 - Multicenter, Randomized Placebo-controlled Clinical Trial to Evaluate the Effect of Perioperative Use of Tranexamic Acid on Transfusion Requirements and Surgical Bleeding in Major Spine Surgery Phase 4
Completed NCT01235650 - Prevalence of Inadvertent Hyperventilation During Intraoperative Anesthetic Care N/A
Completed NCT03459404 - Sufentanil NanoTab PCA System/15 mcg for Acute Post-Operative Pain in Vertebral Surgery: A Preliminary Investigation
Recruiting NCT05010148 - A Clinical Trial of Intravenous Lidocaine After Spinal Surgery to Prevent Delirium and Reduce Pain Phase 3
Recruiting NCT04605120 - Allogeinic Bone Paste N/A
Completed NCT03826329 - Risk Factors of Second Surgery for Adjacent Segment Disease Following Anterior Cervical Discectomy and Fusion
Recruiting NCT04601363 - Personalized Spine Study Group (PSSG) Registry
Recruiting NCT05323448 - Efficacy of ARISTA-AH for Restoring Hemostasis Following Posterior Long-segment Spinal Fusion. N/A
Completed NCT00994656 - Is Pleth Variability Index (PVI) a Surrogate for Pulse Pressure Variations (PPV) in Pediatric Spine Fusion (SF) Surgery? N/A
Completed NCT00152152 - Use of Radiostereometric Analysis Beads (RSA) to Measure Motion in the Spine, Following Lumbar Spinal Surgery N/A
Terminated NCT03425799 - Efficacy and Safety of Tranexamic Acid in Spinal Fusion Surgery Phase 3
Not yet recruiting NCT06368245 - Durability of Suppl. Rod Constructs-SuppleMentAry Rod Technique for Long-segment Posterior Instrumented Spinal Fusions
Withdrawn NCT03908203 - Minimally Invasive Surgery Techniques for One-level Degenerative Lumbar Deformities Correction N/A
Terminated NCT03378973 - The Effects of Dexmedetomidine Dose on Motor Evoked Potentials Phase 4
Completed NCT05936047 - Bone Marrow Clot for Posterior Lumbar Fusion N/A
Not yet recruiting NCT03692845 - Minimally Invasive Versus Open Transforaminal Lumbar Interbody Fusion N/A
Completed NCT00152165 - Use of Radiostereometric Analysis (RSA) Following Spinal Fusion Versus the DYNESYS Stabilization System N/A