Evaluation, the Histomorphometric Study of Nanocrystalline Hydroxyapatite (Nano Bone) Wif Lovastatin in the Preservation of the Tooth Socket

Bone Loss Clinical Trial

Official title:

the Histomorphometric Study of Nanocrystalline Hydroxyapatite (Nano Bone) With Lovastatin in the Preservation of the Tooth Socket

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT03981601
• Other study ID #: 2038
• Status: Recruiting
• Phase: Phase 2
• Start date: February 22, 2018
• Est. completion date: July 30, 2019

Study information

• Verified date: June 2019
• Source: Islamic Azad University, Tehran
• Contact: Amirhossein Farahmand, Assistant Prof
• Phone: +98 912 404 0359
• Email: perio-implant[@]hotmail.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Twenty patients referring to periodontics department of Boroujerd Azad university of dentistry after obtaining consent to participate in the research project, which have more than 20 teeth, are over 18 years old and require socket preservation surgery to tooth extraction for the periodontal problem, caries or Fractures were selected.

Description:

twenty healthy patients referring to periodontics department of Boroujerd Azad university of dentistry after obtaining consent to participate in the research project, which has more than 20 teeth, are over 18 years old and require socket preservation surgery to tooth extraction for the periodontal problem, caries or Fractures were selected. moreover, divided the socket randomly to two groups(A, B)including A: bone graft with lovastatin and B: bone graft alone, after 3 months with trephine will collect the samples. following the histomorphometric analysis.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 20
• Est. completion date: July 30, 2019
• Est. primary completion date: March 30, 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 60 Years

Eligibility

Inclusion Criteria:

1. at least 18 years old

2. tooth fracture, root caries

3. Patients are volunteered for placement of the implant

Exclusion Criteria:

1. systemic diseases

2. Pregnancy and breastfeeding

3. malignancy, radiation therapy,

4. history of periodontal surgery during the six months ago.

5. medicine(phosphonates, antibiotic,...)

Related Conditions & MeSH terms

• Bone Loss

Intervention

Drug:
• Lovastatin 40 MG
after tooth extraction, put teh lovastatin40 mg wif bone graft wifin tooth socket

Procedure:
• without drug with Bone graft
after tooth extraction, put teh bone graft wifin tooth socket

Locations

Country	Name	City	State
Iran, Islamic Republic of	Amirhossein Farahmand	Tehran

Sponsors (1)

Lead Sponsor	Collaborator
Islamic Azad University, Tehran

Country where clinical trial is conducted

Iran, Islamic Republic of, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Socket preservation with Lovastatin as evaluated by the amount of bone formation volume		3 month