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Bone Mass Accrual in Adolescent Athletes — 838  

Bone Loss Clinical Trial

Official title:
"2008P-00346: Bone Mass Accrual in Adolescent Athletes"

Clinical Trial Summary

The adolescent and young adult years are a critical window in time for bone mineral accrual. More than 90% of peak bone mass is achieved by 18 years, and data indicate that insults sustained during adolescence and young adulthood may result in permanent deficits in bone accrual. Adult athletes with amenorrhea (AA) have low bone mineral density (BMD) secondary to hypogonadism, associated with increased fracture risk and associated co-morbidities. We will examine whether estrogen replacement will increase BMD and improve measures of bone microarchitecture in adolescents and young women with AA, thus optimizing peak bone mass.

Clinical Trial Description

Young female athletes 18-21 years old will be randomized to estrogen (and progesterone) with lifestyle modification versus lifestyle modification alone for a 12 month period. Bone density and structure will be assessed over this period. Hormonal evaluations will also be performed. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00827151
Study type Interventional
Source Massachusetts General Hospital
Contact
Status Withdrawn
Phase Phase 3
Start date December 2008
Completion date January 2015
View Details
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