Bone Loss, Alveolar Clinical Trial
Official title:
Histological and Raman Spectroscopy Evaluation of Edentulous Alveolar Ridge Horizontal Bone Augmentations Using a Xenogeneic Bone Substitute and Autologous Platelet Concentrates: A Prospective Case Series
NCT number | NCT05612737 |
Other study ID # | HORAUG |
Secondary ID | |
Status | Completed |
Phase | N/A |
First received | |
Last updated | |
Start date | October 1, 2019 |
Est. completion date | October 31, 2021 |
Verified date | November 2022 |
Source | Semmelweis University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
This case series aimed to assess the efficacy of a novel horizontal ridge augmentation modality using histomorphometry and Raman spectroscopy. Combinations of "sticky bone" and tenting screws without autologous bone were used as augmentative materials.
Status | Completed |
Enrollment | 5 |
Est. completion date | October 31, 2021 |
Est. primary completion date | April 30, 2021 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 70 Years |
Eligibility | Inclusion Criteria: - one or more missing teeth in the jaw's posterior area, where horizontal bone width is =5 mm. - no deficiency in the vertical dimension. - The tooth must have been removed =4 months before augmentation. - The patient should understand the nature of the research and be compliant in study-related activities Exclusion Criteria: - pregnancy - smoking - uncontrolled diabetes - systemic diseases or drug consumption affecting bone metabolism, and clinically relevant osteoporosis |
Country | Name | City | State |
---|---|---|---|
Hungary | Semmelweis University Department of Periodontology | Budapest |
Lead Sponsor | Collaborator |
---|---|
Semmelweis University | FORM-Lab, Purgo Biologics Inc. |
Hungary,
Farias D, Caceres F, Sanz A, Olate S. Horizontal Bone Augmentation in the Posterior Atrophic Mandible and Dental Implant Stability Using the Tenting Screw Technique. Int J Periodontics Restorative Dent. 2021 Jul-Aug;41(4):e147-e155. doi: 10.11607/prd.5137. — View Citation
Ghanaati S, Booms P, Orlowska A, Kubesch A, Lorenz J, Rutkowski J, Landes C, Sader R, Kirkpatrick C, Choukroun J. Advanced platelet-rich fibrin: a new concept for cell-based tissue engineering by means of inflammatory cells. J Oral Implantol. 2014 Dec;40(6):679-89. doi: 10.1563/aaid-joi-D-14-00138. — View Citation
Gheno E, Alves GG, Ghiretti R, Mello-Machado RC, Signore A, Lourenço ES, Leite PEC, Mourão CFAB, Sohn DS, Calasans-Maia MD. "Sticky Bone" Preparation Device: A Pilot Study on the Release of Cytokines and Growth Factors. Materials (Basel). 2022 Feb 16;15(4). pii: 1474. doi: 10.3390/ma15041474. — View Citation
Khoury F, Hanser T. Mandibular bone block harvesting from the retromolar region: a 10-year prospective clinical study. Int J Oral Maxillofac Implants. 2015 May-Jun;30(3):688-97. doi: 10.11607/jomi.4117. — View Citation
Tan WL, Wong TL, Wong MC, Lang NP. A systematic review of post-extractional alveolar hard and soft tissue dimensional changes in humans. Clin Oral Implants Res. 2012 Feb;23 Suppl 5:1-21. doi: 10.1111/j.1600-0501.2011.02375.x. Review. — View Citation
Urban IA, Nagursky H, Lozada JL, Nagy K. Horizontal ridge augmentation with a collagen membrane and a combination of particulated autogenous bone and anorganic bovine bone-derived mineral: a prospective case series in 25 patients. Int J Periodontics Restorative Dent. 2013 May-Jun;33(3):299-307. doi: 10.11607/prd.1407. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Amount of newly formed bone by means of histomorphometry | The percentage of newly formed bone of the augmented site within the biopsy | 5 months postoperatively | |
Primary | Amount of graft material bone by means of histomorphometry | The percentage of graft material (THE Graft; Purgo Biologics Inc.) of the augmented site within the biopsy | 5 months postoperatively | |
Primary | Amount of soft tissue by means of histomorphometry | The percentage of soft tissue of the augmented site within the biopsy | 5 months postoperatively | |
Primary | The quality of the newly formed tissues by means of histology | The descriptive analyses of the cells and tissue structure of the augmented site within the biopsy | 5 months postoperatively | |
Secondary | In vivo spectroscopy analyses of the augmented site with a Raman spectrometer device | Raman investigation (measuring wavelength in the range 300-1800 cm-1) highlights the peaks (Raman shift) for the main bone components (chemical groups and elements) in order to evaluate differences between bone tissue for the investigated patients. Differences in peaks intensity on raw spectra reflected the differences in the quantities of the chemical components for investigated specimens. | 5 months postoperatively | |
Secondary | CBCT analysis | Horizontal bone volume gain (measured in mm) evaluated on pre- and postoperative CBCT-s. | 5 months postoperatively | |
Secondary | The clinical descriptive bone assessment of the augmented bone site | The descriptive clinical assessment is a subjective evaluation of the augmented bone judged by the operator. The presence of possibly occuring non-integrated graft remnants can be assessed during reentry surgery. | 5 months postoperatively | |
Secondary | The clinical descriptive bone assessment of the augmented bone site | The descriptive clinical assessment is a subjective evaluation of the augmented bone judged by the operator. The bleeding property of the newly formed bone after drilling the osteotomy for the implant can be assessed during reentry. | 5 months postoperatively |
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