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Bone Injury clinical trials

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NCT ID: NCT06249906 Recruiting - Clinical trials for Osteo Arthritis Knee

Efficacy of Bioceramic Materials for Bone Defects Repair

Start date: February 20, 2024
Phase: N/A
Study type: Interventional

The purpose of this study is to demonstrate the effect of bioceramic implants on the repair of human bone defects, and to explore the application of bioceramic materials in bone defects, bone implantation, and bone fusion. The surface microstructure of β-tricalcium phosphate bioceramic implants can be effectively controlled to guide the regeneration of bones, promote the restoration of bones, accelerate the speed of recovery, and improve bone quality, which is of great clinical and social significance.

NCT ID: NCT05792371 Not yet recruiting - Bone Injury Clinical Trials

The Role of Type H Vessel Formation in Induced Membrane of Patients With Critical Size Bone Defect

Start date: April 1, 2023
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to test the role of type H vessel and investigate the mechanism of its regulation in induced membrane created by induced membrane technique in patients with open fracture, aged between 20 and 80. The main questions to answer are: - Whether type H vessel will be critical for induced membrane-mediated bone healing? - Whether type H vessel will be a biomarker for diagnosing bone healing in patients with open fracture? - To find out a circulating indicator for type H vessel in patients with open fracture undergoing induced membrane technique. Participants will be enrolled to collect tissues of induced membrane and blood samples to detect type H vessel and measure the biomarkers of type H vessel, investigating their correlation with the capacity of bone healing. To avoid selection bias of treatment, the grouping will be achieved by a randomized protocol qualified clinical trial center of Chang Gung Memorial Hospital to divide into with induced membrane and without induced membrane. Researchers will compare these two groups to test our hypothesis that type H vessel in important in induced membrane and their corresponding biomarkers.

NCT ID: NCT05512013 Completed - Bone Resorption Clinical Trials

The Effects of NSAIDs on Bone Metabolism Following Exercise

Start date: February 15, 2022
Phase: Phase 1
Study type: Interventional

The purpose of this study is to determine the effects of a single dose of non-steroidal anti-inflammatory drugs on post-exercise markers of bone and muscle metabolism.

NCT ID: NCT05440435 Recruiting - Clinical trials for Artificial Intelligence

Application of Mobile DR in the Diagnosis of Bone Trauma in High Cold Environment

Start date: January 1, 2022
Phase:
Study type: Observational

In the high cold environment, mobile digital radiography (DR) is used to collect the imaging of bone injury patients, and the artificial intelligence diagnosis module is used to diagnose the injury. The quality of images obtained by mobile or conventional DR and the consistency between artificial intelligence and pure artificial diagnosis will be analyzed respectively. Finally, the application value of mobile DR loaded with artificial intelligence diagnosis function in high cold environment is determined.

NCT ID: NCT05369091 Completed - Bone Injury Clinical Trials

Salivary Bmp-2 Levels & Radiographic Measurement Of Bone Density at Extracted Tooth

salivaryBMP2
Start date: December 16, 2020
Phase: Phase 4
Study type: Interventional

Salivary Bmp-2 Levels & Radiographic Measurement Of Bone Density were evaluated At Extracted Tooth Socket in patients With & Without topical Application Of Simvastatin

NCT ID: NCT03741504 Terminated - Clinical trials for Orthodontic Pathological Resorption of External Root

Biological Anchorage With Selective Micro-osteoperforations (MOPs) in Canine Distalization

Start date: December 2, 2019
Phase: N/A
Study type: Interventional

To evaluate the effect of selective micro-osteoperforations (MOPs) on the amount of distal movement of the upper canine, the mesio-distal inclination of the canine and the messiah movement of the upper first molar. Methods: Clinical trial with Split mouth design in 35 orthodontic patients with bilateral extraction of the upper first premolar, each upper canine will be randomly assigned to the intervention (MOP) or to the control side. Participants will be followed for 3 months and the investigators will take periapical radiographs, cast models and clinical measurements before and after canine retraction. The measurements will be taken by previously calibrated operators. The results are going to be determined and compared between sides, with the corresponding statistical tests and the results are going to be analyzed.