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Gut Microbiome of Patients Undergoing Antibiotic Therapy for Orthopedic Device-related Infection — IMPAT-ODRI  

Fractures, Bone Clinical Trial

Official title:
Investigation of the Microbiome of Patients Receiving Antibiotic Therapy for Orthopedic Device-related Infection

Clinical Trial Summary

The microbiome of 80 orthopedic-device related infection (ODRI) patients treated with antibiotics and 10 healthy controls will be investigated. Samples (blood, stool, saliva, skin-swab) are collected 4x within 6 months. Composition and diversity of the microbiome will be assessed by 16sRNA sequencing, skins swabs are screened for rifampicin-resistant staphylococci onto Mannitol-salt-agar plates supplemented with rifampicin, inflammation markers and antibodies in blood and saliva are monitored to track changes in the immune response. For further analysis patients are assigned to one of two groups: 1) antibiotic therapy including rifampicin and 2) non-rifampicin antibiotic therapy.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04440631
Study type Observational
Source AO Research Institute Davos
Contact
Status Completed
Phase
Start date November 1, 2019
Completion date December 31, 2022
View Details
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