Clinical Trials Logo
  1. Home
  2. Bone Infection
  3. NCT04440631

Gut Microbiome of Patients Undergoing Antibiotic Therapy for Orthopedic Device-related Infection — IMPAT-ODRI  

Fractures, Bone Clinical Trial

Official title:
Investigation of the Microbiome of Patients Receiving Antibiotic Therapy for Orthopedic Device-related Infection

Clinical Trial Summary

The microbiome of 80 orthopedic-device related infection (ODRI) patients treated with antibiotics and 10 healthy controls will be investigated. Samples (blood, stool, saliva, skin-swab) are collected 4x within 6 months. Composition and diversity of the microbiome will be assessed by 16sRNA sequencing, skins swabs are screened for rifampicin-resistant staphylococci onto Mannitol-salt-agar plates supplemented with rifampicin, inflammation markers and antibodies in blood and saliva are monitored to track changes in the immune response. For further analysis patients are assigned to one of two groups: 1) antibiotic therapy including rifampicin and 2) non-rifampicin antibiotic therapy.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04440631
Study type Observational
Source AO Research Institute Davos
Contact
Status Completed
Phase
Start date November 1, 2019
Completion date December 31, 2022
View Details
See also
  Status Clinical Trial Phase
Recruiting NCT05555459 - Performance and Safety Evaluation of Inion CompressOn Screw in Foot and Ankle Surgeries. PMCF Investigation N/A
Completed NCT03147222 - Function Focused Care: Fracture Care at Home N/A
Completed NCT03506958 - Patient Satisfaction in Treatment of Non-complex Fractures and Dislocations in Hospitals vs General Practitioners
Completed NCT04426981 - Behavioral Activation in Orthopaedic Trauma Patients: A Pilot Study N/A
Recruiting NCT04389749 - Continuous Passive Motion Following Fixation of Pelvic and Knee Fractures N/A
Recruiting NCT05068180 - Low-dose Neuroleptanalgesia for Postoperative Delirium in Elderly Patients Phase 4
Recruiting NCT05594199 - Feasibility of a Virtual Smoking Cessation Program N/A
Completed NCT04514601 - A Quality Improvement Project to Assess and Refine the Handover Process at Morning Trauma Meetings
Completed NCT05138640 - Bone Strength and Physical Activity in Patients With a Recent Clinical Fracture
Completed NCT02272972 - Performance Improvement Program on Imaging II
Completed NCT04215315 - Fracture In Preterm Infants Study (FIPIN Study)
Completed NCT03219125 - Bone Marrow Adiposity and Fragility Fractures in Postmenopausal Women
Terminated NCT05655130 - Distal Radius Steroid Phase 1
Completed NCT04151732 - Factors Associated With Future Fractures in Middle-aged Men and Women
Completed NCT02714257 - Working to Increase Stability Through Exercise N/A
Completed NCT02428244 - Let's STOP Now Trial: Smoking in Trauma Orthopaedic Patients N/A
Recruiting NCT04501510 - Ultrasonography in Fracture Management
Completed NCT03852095 - Single Time Management Diseases in Pediatric Traumatology
Completed NCT03370900 - Learning Retention in Radiograph Interpretation N/A
Completed NCT03819478 - Utilizing Protein During Weight Loss to Impact Physical Function and Bone N/A