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Bone Fragile clinical trials

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NCT ID: NCT05585697 Completed - Clinical trials for Diabetes Mellitus, Type 2

Bone Turnover in Type 2 Diabetes and Non-diabetes Controls (DiaMarv)

DiaMarv
Start date: October 7, 2022
Phase:
Study type: Observational

Type 2 diabetes (T2D) is related to an increased risk of major fractures which does written in English. The summary is used not only increase society health care costs, but also increase the morbidity and in the recruitment of peer reviewers.: mortality for patients with T2D. Traditional fracture predictors underestimate the risk in T2D. Thus, the bone affection is not caused by decreased bone mineral density but rather by impaired bone quality leading to fragile bone. In diabetes, circulating bone turnover markers are suppressed and advanced glycation endproducts may accumulate in the tissue. The study aims at exploring whether bone turnover in T2D is compromised in the circulation, bone marrow, and bone tissue and whether advanced glycation endproducts accumulate in these tissues. Furthermore, the investigators will assess whether bone turnover markers predict fractures in a cohort of individuals with diabetes. The project will contribute to the knowledge on bone disease in T2D and will ultimately benefit the patients by improving future fracture prevention strategies.

NCT ID: NCT04012320 Completed - Children Clinical Trials

Efficacy and Safety on the Use of Bisphosphonates in Paediatrics

Bisphosphonate
Start date: October 31, 2018
Phase:
Study type: Observational

The investigators suppose that the impact of bisphosphonate therapy is beneficial on the bone during the growth period with few adverse events.