Bone Diseases Clinical Trial
Official title:
How Does Early Age Life Style Affect Bone Strength and General Health at Middle Age? Twenty-Five Year Follow-up Health Status Comparison of a Sedentary Versus Extremely Physically Active Population From an Early Age
The purpose of this study is to evaluate the effect of vigorous physical activity versus extremely sedentary life style during young age on the bone mineral density and general health in later life.
Bone strength and peak bone mass are preliminary determined by genetic factors. Life style,
especially exercise, is also considered to have an important effect on bone strength. Bone
has the ability to strengthen itself according to Wolff's Law. When bone is subjected to
strains and/or strain rates higher than the usual, it responds by remodeling, strengthening
its architecture. The ability is greatest in young individuals and decreases with age. In
the elderly this ability is largely non-existent and bone mass is lost. Whether this loss
leads to osteoporosis is largely a function of the peak bone mass achieved before the
decline. 11% of males and 44 % of females over 50 suffer from osteoporosis in later life. To
what extent vigorous exercising beginning at a young age can increase bone strength is not
known.
The purpose of the proposed research is to quantify the effect of life style on bone
strength and general health parameters by comparing two male populations, one sedentary and
the other that has done demanding physical training: (1) Elite infantry recruits who were
inducted into the I.D.F. in Feb 1983, did their basic training at Sanur and were part of the
1983 stress fracture project who completed three years of elite infantry service and
continued to serve as combat soldiers in the reserves; (2) Yeshiva students who had profiles
of 82 or 97 and received deferment from their military service in 1983 and since then have
continued their studies and never served in the army.
50 subjects will be reviewed in each group. Measurements of weight, height, waist and
abdominal girth, resting pulse and blood pressure will be made. The brachial/ankle blood
pressure index will be recorded. MRI of the right knee to study potential degenerate changes
will be done using a 1.5 Tesla General Electric Signa MR scanner. Quantitative Computed
Tomography (QCT), one of the most popular and effective methods utilized for osteoporosis
screening, will be performed to determine volumetric BMD, BMC, bone geometric properties and
strength indexes of the tibia and lumbar spine.
Comparisons:
Group I: 50 males (age 41-45), former elite Israeli infantry soldiers, selected randomly
from those recruits who did their infantry basic training at Sanur in Feb. 1983 (all
profiled 82 or 97) and completed their military service as combat soldiers will be compared
to:
Group II: 50 age-, profile- and ethnically-matched Israeli citizens whose military service
was deferred in 1983 because of Torah studies and who did not do army service and were not
involved in any kind of physical training.
;
Observational Model: Cohort, Time Perspective: Prospective
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT03672513 -
Short-term Supplementation, Bone Turnover and Antioxidant Status in Menopause
|
N/A | |
Completed |
NCT00070681 -
Outcomes of Sleep Disorders in Older Men
|
Phase 3 | |
Recruiting |
NCT03905174 -
Massive Implants the Next Generation
|
N/A | |
Completed |
NCT03050203 -
Custom Pack in Spine Surgery
|
N/A | |
Completed |
NCT00000466 -
Postmenopausal Estrogen/Progestin Interventions (PEPI)
|
Phase 3 | |
Recruiting |
NCT03904914 -
Thumb Ossification Composite Index (TOCI) to Predict Skeletal Maturity and Curve Progression in AIS
|
||
Completed |
NCT04608708 -
3D Analysis of Cemento-Osseous Lesions
|
||
Completed |
NCT02252679 -
Study of the Diagnostic Value of Stable Calcium Isotope Profiling in Bone and Calcium Disorders
|
||
Completed |
NCT03633032 -
Radiation-free Bone Imaging UTE MRI in Healthy and Diseased Patients
|
N/A | |
Recruiting |
NCT03431727 -
Acromegaly - Before and After Treatment
|
||
Completed |
NCT03072186 -
Proposal for Intraoperative Administration of Intravenous Indocyanine Green to Evaluate Position of the Optic Canal, Position of the Internal Carotid Arteries, Tumor Vascularization, and Vessel Encasement in Endoscopic Endonasal Cranial Base Surgery
|
N/A | |
Completed |
NCT03438123 -
Data Collection Study for the Spectrum Dynamics Multi-purpose CZT SPECT Camera
|
N/A | |
Recruiting |
NCT06116071 -
Biomarkers Related to Bone in Pediatric Gaucher Disease
|
||
Not yet recruiting |
NCT05840003 -
Image Quality: Ultra-Low Dose Scanner Versus Standard Dose Conventional Scanner for Thoraco-abdominopelvic Scans
|
N/A | |
Withdrawn |
NCT04955652 -
Evaluation of Alerts in Promoting Bone Densitometry Scans
|
N/A | |
Active, not recruiting |
NCT00150163 -
Odense Androgen Study: Study of Androgens, Body Composition, and Muscle Function in Danish Men
|
N/A | |
Completed |
NCT00155961 -
Odense Androgen Study in the Elderly
|
Phase 1 | |
Terminated |
NCT03802656 -
Vertebral Body Tethering Treatment for Idiopathic Scoliosis
|
N/A | |
Not yet recruiting |
NCT05802121 -
Akkermansia Muciniphilia and Metabolic Side Effects of ADT
|
Early Phase 1 | |
Recruiting |
NCT02809781 -
A Pilot Study of MSCs Iufusion and Etanercept to Treat Ankylosing Spondylitis
|
Phase 2/Phase 3 |