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Bone Demineralization clinical trials

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NCT ID: NCT06033521 Completed - Menopause Clinical Trials

A Study to Learn More About the Menopausal Hormone Therapies in Korea

Start date: September 12, 2023
Phase:
Study type: Observational

The purpose of this study is to learn about how the commonly used menopausal hormone therapies were prescribed and taken in practice. This is done by using healthcare database, to study the overall dangers and benefits of menopausal hormone therapies in real-world practice. This study will include subjects who were newly diagnosed menopausal symptoms between 2012 and 2019. They were all followed up for 12 months at least. The study included the below subjects who: - were aged 40-59 years - were diagnosed to have menopausal symptoms through some medical check-ups The data collected will be used to understand: - how the commonly used menopausal hormone therapies were prescribed and taken in practice - how patients took medication as prescribed by their doctors This might help to understand treatment trends of these therapies.

NCT ID: NCT03464266 Completed - Hypoestrogenism Clinical Trials

The Kampala Women's Bone Study

Start date: May 15, 2018
Phase: Phase 4
Study type: Interventional

The primary objective of this study is to address critical safety questions with concurrent TDF-based PrEP and DMPA use. We hypothesize that young women using TDF-based PrEP and DMPA will have lower bone acquisition and altered bone metabolism. Bone mineral metabolism is in part regulated by the kidney, and we hypothesize that bone effects from concurrent PrEP and DMPA use will be driven by subclinical kidney injury, a known side effect of TDF, as well as DMPA-induced hypoestrogenism. To investigate our hypothesis, we will enroll a prospective cohort of approximately 500 HIV-uninfected women ages 16-25 years in Kampala, Uganda who have substantial HIV risk and are initiating DMPA or barrier method contraception. Over a 24-month period, we will offer TDF-based PrEP. We will use state-of-the-art radiologic, biochemical, and epidemiologic methods to test the hypothesis that concurrent TDF-based PrEP and DMPA use results in compounding adverse effects on bone health.

NCT ID: NCT02322099 Terminated - Clinical trials for Bone Demineralization

Alendronate for Prevention of AntiRetroviral Therapy-associated Bone Loss

APART
Start date: May 2016
Phase: Phase 4
Study type: Interventional

Antiretroviral therapy (ART) initiation is associated with a significant loss of bone mineral density (BMD), characterised by increases in bone turnover, which is largely limited to the first 48 weeks of therapy. Bisphosphonates, such as alendronate, decrease bone turnover and can limit loss of bone mineral density. This study aims to determine if a short course of treatment with the oral bisphosphonate alendronate can limit loss of bone mineral density associated with initiation of ART in HIV-1 infected, antiretroviral naive, adult subjects.

NCT ID: NCT00536276 Completed - Burns Clinical Trials

Evaluation of Vitamin D Status in Children With Acute Burns

VitaminD
Start date: March 2003
Phase: Phase 1
Study type: Interventional

To see which vitamin D supplement (D2 vs D3) is most beneficial in burned children.