Smoking Cessation Clinical Trial
Official title:
The Effect of Cigarette Smoking / Smoking Cessation on Skeletal Muscle Mass, Strength and Functional Capabilities
Tobacco smoke is probably the single most significant source of toxic chemicals that humans
are exposed to. Smoking is associated with a variety of pathological conditions such as
cardiovascular and pulmonary diseases. In addition to the known harmful effects of cigarette
smoking, several epidemiological studies identified tobacco use as a risk factor for
sarcopenia, the loss of skeletal muscle mass and strength with advancing age. Previous
studies examined skeletal muscles of smokers in comparison with muscles of non-smokers and
found structural and metabolic damage in muscles of smokers.
Quitting of smoking is known to be associated with weight gain. A previous study examined
the effects of smoking cessation on body composition of post-menopausal women using
dual-energy x-ray absorptiometry (DEXA). It was found that women who successfully quit
smoking for a period of 16 months have significantly increased their body weight, fat mass,
muscle mass and functional muscle mass in comparison with non-quitters women. For the first
time, it was shown that smoking cessation is associated with an increase of functional
muscle mass. Yet, the effects of quitting of smoking on muscle mass and muscle functional
capabilities of younger subjects remain unclear. Therefore, we aim to investigate the
effects of smoking cessation on muscle mass, muscle function and strength in heavy smoker's
subjects. Our findings may shed light on the beneficial effects of smoking cessation
regarding the status and function of skeletal muscle in heavy smokers and as a possible
strategy to prevent or delay the progression of sarcopenia.
Research hypothesis: Smoking cessation among adult heavy smokers will lead to increase in
skeletal muscle mass and improvement of muscle function and strength compared with continued
smokers.
Body composition and muscle function were assessed at the beginning of a smoking cessation program and again after 12 months. Changes in body composition and muscle function were compared between continued smokers and quitters. ;
Time Perspective: Prospective
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