Osteoporosis Clinical Trial
Official title:
The Relationship Between Bone Mineral Density, Disease Duration, and Activity in Patients With Ankylosing Spondylitis
Our clinical study aimed to evaluate the prevalence of osteoporosis (OP) in patients with ankylosing spondylitis (AS) and to investigate the relationship between clinical, disease activity, physical function and disease duration, and bone mineral density (BMD).
In this cross-sectional study, patients who were admitted to the rheumatology clinic between
18 and 65 years of age and diagnosed as AS according to the modified New York diagnostic
criteria were included
Patients group was divided two part as patients with (group 1)and without (group 2)
osteoporosis.
The patient's global rating scale is a self-assessed scale of the patient with a grade of 10
(1: very bad, 5: moderate, 10: very good). To assess the disease activity, Bath ankylosing
spondylitis disease index (BASDAI) and Bath ankylosing spondylitis functional index (BASFI)
were evaluated. BASDAI is a self-assessment scale used to determine disease activity in
patients with AS.
Schober measurement was used to evaluate lumbar mobility of the patients. Chest expansions
were measured in all patients.
Body mass index (BMI) was calculated as kg/height m2. Erythrocyte sedimentation rate (ESH mm
/ h), C-reactive protein (CRP mg / l) levels were measured in all patients.
BMD measurements were made by using dual-energy x-ray absorptiometry (DEXA) and lumbar
vertebra (L1-4) and left femur (femoral neck and total) regions. DEXA measurements (GE /
LUNAR DPX PRO) were performed and the results were recorded using standard T score. Bone
mineral densities of patients were based on the World Health Organization (WHO)
classification of a T score between -1 and -2.5 for osteopenia; and a score of -2.5 for
osteoporosis.
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