To Establish a Blood Transfusion Prediction Model for Liver Transplantation Patients Based on PBM

Blood Transfusion Complication Clinical Trial

Official title:

To Establish a Prediction Model of Massive Blood Transfusion for Liver Transplantation Patients Based on Patient Blood Management

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT03814772
• Other study ID #: ThirdXiangyaLTP
• Status: Recruiting
• Start date: March 20, 2019
• Est. completion date: December 31, 2021

Study information

• Verified date: February 2019
• Source: The Third Xiangya Hospital of Central South University
• Contact: Rong Gui, doctor
• Phone: +8615200828442
• Email: aguirong[@]163.com
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

Based on the principle of patient blood management, this study aims to reduce the risk of blood transfusion in allogeneic liver transplantation patients, to ensure the safety of blood transfusion, and to provide new methods and basis for restrictive blood transfusion.

Description:

1. Preoperative variables and statistical analysis of a large number of intraoperative blood transfusions in allogeneic liver transplantation patients were performed to screen preoperative variables.

2. Models were established by machine learning algorithms to predict a large number of blood transfusions during surgery, providing a reference for preoperative blood preparation and postoperative outcome.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 2000
• Est. completion date: December 31, 2021
• Est. primary completion date: December 1, 2019
• Gender: All
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

• 48h preoperative biochemical indicators, blood general indicators, coagulation test complete

Exclusion Criteria:

• 1. Inspection information is not detailed 2. Blood transfusion information is not detailed 3.Postoperative medical record information is not detailed

Related Conditions & MeSH terms

• Blood Transfusion Complication
• Transfusion Reaction

Intervention

Procedure:
• Liver transplant
blood transfusion

Locations

Country	Name	City	State
China	the Third Xiangya Hospital of Central South University	Changsha	Hunan

Sponsors (4)

Lead Sponsor	Collaborator
The Third Xiangya Hospital of Central South University	Qilu Hospital of Shandong University, RenJi Hospital, Second Xiangya Hospital of Central South University

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	one year mortality	All-cause mortality	2019-2021
Secondary	Intraoperative blood transfusion	Intraoperative blood component input	2019-2021